Msd K.k.

Takahide Sasaki

Toshiyuki Takahashi

Tsuyoshi Nagase

Nagaaki Sato

Takashi Mizutani

[Problem] There is provided a compound useful as a preventive or remedy for cardiovascular disease, neurologic disease, metabolic disease, reproductive disease, and digestive disease. [Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I) wherein Z represents wherein n1, n2, and n3 are 0, 1, or 2, respectively; Rrepresents Calkyl, Ccycloalkyl, or the like; Rrepresents aryl or heteroaryl; Rrepresents a hydrogen atom, Calkyl, or the like; and M, M, M, and Mindependently represent a hydrogen atom, Calkyl, or the like, or M, together with M, M, or M, forms &#x2014;CH&#x2014; or the like.

3-substituted sulfonyl piperidine derivative

[PROBLEMS] To provide compounds useful as preventives or remedies for circulatory diseases, nervous diseases, metabolic diseases, reproductive system diseases, and digestive diseases. [MEANS FOR SOLVING PROBLEMS] Compounds represented by the general formula (I) or pharmaceutically acceptable salts thereof: wherein R1 is C1-6 alkyl, C3-8 cycloalkyl, or the like; R2 is phenyl, heteroaryl, or the like; Q is N or CH; and M1, M2, M3 and M4 are each independently hydrogen or C1-6 alkyl, or alternatively M1 together with M2 or M3 forms &#x2014;CH2-CH2- or the like, or M4 together with M2 or M3 forms &#x2014;CH2-CH2- or the like, with the proviso that M1, M2, M3, and M4 are such that one &#x2014;CH2- or &#x2014;CH2-CH2- group is formed thereamong.

4-sulfonylpiperidine derivatives

Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof.  This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; Xrepresents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; Xrepresents a group represented by the following formula (II): (wherein Rand Rrespectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X-Xrespectively represent &#x2014;CH&#x2014;, a nitrogen atom or the like. 

Benzoxathiin derivative

[Problem] To provide a compound that is useful as an agent in the prevention and treatment of circulatory system, nervous system, metabolic, reproductive system, and gastrointestinal diseases. [Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I): [wherein, Z represents formula (II-1), (II-2), or (II-3), wherein m and n are 0, 1, or 2,Y represents CRor N, Rrepresents a Calkyl, Ccycloalkyl, etc., Rrepresents phenyl or a heteroaryl, etc., Rand Reach independently represent a hydrogen atom, a Calkyl, etc., M, M, M, and Meach independently represent a hydrogen atom, a Calkyl, etc.]

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Kawasaki, Japan

Takahide Sasaki