Fujisawa Pharmaceutical Company, Ltd.

Takaharu Ono

Haruo Horiai

Mitsuyoshi Nakashima

Masato Terakawa

Akira Sugiyama

Mitsutaka Kanamaru

Minoru Ohtsuka

Toshiharu Kamitani

Minoru Otsuka

Dihydropyridine compounds of the formula ##STR1## in which R.sup.1 is a nitrophenyl group and R.sup.2, R.sup.3, and R.sup.4 are lower alkyl groups or pharmaceutically acceptable salts thereof are useful for improving venous extensibility and suppressing cardiac hypertrophy.

Venous extensibility improving and cardiac hypertrophy suppressant agent

A method for treating edema or hypertension which comprises administering an effective amount of a quinazoline derivative of the general formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each is a hydrogen atom or a halogen atom or a pharmaceutically acceptable salt thereof to a human being in need of said treatment.

Diuretic or antihypertensive composition

The treatment of cerebral dysfunction with a dihydropyridine compounds the formula: ##STR1## R.sup.1 is nitrophenyl and R.sup.2, R.sup.3 and R.sup.4 are each lower alkyl or a pharmaceutically acceptable salt thereof.

Cerebral dysfunction therapeutic agent, which comprises a

Growing community of inventors

Osaka, Japan

Takaharu Ono