The United States of America, as Represented by the Secretary, Department of Health and Human Services

University of the Ryukyus

Takafumi Tsuboi

David C Kaslow

Motomi Torii

Takeshi Arakawa

Takeshi Miyata

Goro Matsuzaki

An objective of the invention is to provide a drug delivery vehicle capable of allowing a vaccine or adjuvant to reach a target cell or tissue efficiently while being capable of improving the immunogenicity of the vaccine or capable of enhancing the immunostimulating effect of the adjuvant as well as a vaccine or adjuvant utilizing the same. Said drug delivery vehicle contains a multimeric protein having a coiled coil structure and a ligand molecule to a receptor of an immune cell.

Drug transporter, and adjuvant and vaccine each utilizing same

The present invention relates novel methods and compositions for blocking transmission ofwhich cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface ofzygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.

[object Object]

The present invention relates to novel methods and compositions for blocking transmission ofwhich cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface ofzygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.

Growing community of inventors

Ehime, Japan

Takafumi Tsuboi