Takeda Pharmaceutical Company Limited

Takafumi Takai

Tatsuki Koike

Yasutaka Hoashi

Osamu Uchikawa

Minoru Nakamura

Makoto Kamata

Takuto Kojima

Yuichi Kajita

Kazuyoshi Aso

Michiyo Mochizuki

Katsumi Kobayashi

Kazuyuki Tokumaru

Yoshihide Tomata

Tetsuya Tsukamoto

The present invention provides a heterocycle derivative having a superior amyloid &#x3b2; production inhibitory activity and/or a superior &#x3b3;-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.

Fused triazoles for the treatment or prophylaxis of mild cognitive impairment

There is provided a compound of the formula (I'): wherein X is a nitrogen or CRx, Rx is a hydrogen, etc., Ris an optionally substituted hydrocarbon group, etc., Ris an optionally substituted hydrocarbon group, etc., ring A is 5- to -8-membered heterocyclic ring, etc., and each of Y, Yand Yis an optionally substituted carbon or a nitrogen, etc.; or 'a salt thereof or a prodrug thereof, which have CRF receptor antagonistic activity and use thereof. 

Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them

The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.

Tricyclic compound and pharmaceutical use thereof

Heterocyclic compound and use thereof

There is provided a compound of the formula (I'): wherein x is a nitrogen or CRx, Rx is a hydrogen, etc., Ris an optionally substituted hydrocarbon group, etc., Ris an optionally substituted hydrocarbon group, etc., ring A is 5- to 8-membered heterocyclic ring, etc., and each of Y, Yand Yis an optionally substituted carbon or a nitrogen, etc.; or a salt thereof or a prodrug thereof, which have CRF receptor antagonistic activity and use thereof.

Tricyclic compounds and use thereof

The present invention provides a compound represented by the formula wherein Ris a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), Ris a hydrogen atom or a hydrocarbon group optionally having substituent(s), Ris a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa to Xe are each a carbon atom or a nitrogen atom, m is 0 to 2, and ring A to ring C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.

Tricyclic compound and medical use thereof

The present invention provides a compound represented by the formula wherein Ris a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), Ris a hydrogen atom or a hydrocarbon group optionally having substituent(s), Ris a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa, Xb, Xc and Xd are each a carbon atom or a nitrogen atom, provided that any one or two of Xa, Xb, Xc and Xd is/are nitrogen atom(s), m is 0 to 2, and rings A to C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.

The present invention provides a compound represented by the formula wherein Ris a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s); Ris a hydrogen atom or a hydrocarbon group optionally having substituent(s); Xa and Xb are each C, N, O or S; Xc and Xd are each C or N; m is 0-2; n is 1-3; ring A is a 5-membered ring optionally having substituent(s); ring B is a 6-membered ring optionally having substituent(s); and ring C is a 3- to 5-membered ring optionally having substituent(s), provided that when Xa, Xc and Xd are each C, then Xb is N or S, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.

Growing community of inventors

Osaka, Japan

Takafumi Takai