Seldar Pharma Inc.

Astellas Pharma Gmbh

Other

Kabushiki Kaisha Toshiba

Takafumi Shimizu

Kyoichi Maeno

Norio Seki

Tsukasa Ishihara

Itsuro Shimada

Hiroyuki Hisamichi

Tomofumi Takuwa

Noriko Ishikawa

Norio Asai

Hiroyuki Koshio

Tomoyuki Saito

Shunichiro Matsumoto

Taisuke Takahashi

Takatoshi Kanayama

Shigeo Matsui

Yasuhito Nagai

Keiko Kawabata

Karl Bruce Thor

Yoshihiro Ueda

Kenji Tsuchida

Hiroaki Tanaka

Daisuke Yamashita

Hiroyuki Moritomo

Hideki Kubota

Kazuhiro Yokoyama

Keizo Sugasawa

Takashi Sugane

Yasuhiro Yonetoku

Takuya Makino

Naomi Hosogai

Daisuke Tanabe

Hisashi Mihara

Naoto Katoh

Kazuhiko Osoda

Chiharu Mori

To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

Tetrahydroisoquinolin-1-one derivative or salt thereof

To provide a compound which can be used as an MCreceptor agonist. The present inventors have investigated MCreceptor agonists, and have found that a piperazine derivative has an action related to the agonists, thereby completing the present invention. That is, the piperazine derivative of the present invention has an MCreceptor agonistic action, and can be used as an agent for preventing or treating bladder and/or urinary tract diseases, in particular, underactive bladder, hypotonic bladder, acontractile bladder, detrusor underactivity, neurogenic bladder, urethral relaxation failure, detrusor-external urethral sphincter dyssynergia, and voiding dysfunctions in benign prostatic hyperplasia.

Piperazine derivative

[Problem] To provide a compound useful as a MTand/or MTreceptor agonist. [Solution] The present inventors have studied on MTand/or MTreceptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, a compound represented by formula (I) or a salt thereof according to the present invention has a MTand/or MTreceptor agonistic activity and has a low ability of migrating into central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MTand/or MTreceptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence. 

Indole compound

Provided is a compound which is useful as an agent for treating or preventing 5-HTreceptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like. The present inventors have investigated compounds having a 5-HTreceptor agonist activity and have found that the benzazepine compounds of the present invention have an excellent 5-HTreceptor agonist activity, thereby completing the present invention. That is, the benzazepine compounds of the present invention have a 5-HTreceptor agonist activity and can be used as an agent for treating or preventing 5-HTreceptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.

Benzazepine compound

The present invention relates to indole carboxamide compounds of formula (I) or a salt thereof wherein R, R, R, R, R, R, Rand Rhave the meanings as indicated herein, and are MT1 and/or MT2 receptor agonists useful for treating and/or preventing urological diseases.

Indole carboxamide derivative

According to one embodiment, a magnetic memory includes a magnetoresistive element includes a fixed layer whose magnetization direction is fixed, a recording layer whose magnetization direction is variable and a nonmagnetic layer disposed between the fixed layer and the recording layer. A direction of a read current is set to a first direction in a case where an expression of MR ratio &#x2267;|I/I|&#x2212;1 is satisfied if a critical current of the first direction used to write the magnetoresistive element to the parallel state is set to Iand a critical current of a second direction used to write the magnetoresistive element to the anti-parallel state is set to I.

Magnetic memory

[Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). [Means for Solving Problems] It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

Growing community of inventors

Tokyo, Japan

Takafumi Shimizu