Fujisawa Pharmaceutical Company, Ltd.

Other

Daicel Chemical Industries, Ltd.

Takafumi Imoto

Noritsugu Yamasaki

Takahiro Hiramura

Hiroshi Kayakiri

Hitoshi Sawada

Teruo Kyoto Oku

Yoshito Abe

Hitoshi Hamashima

Masahiro Nishikawa

Osamu Onomura

Hiroyuki Setoi

Naoki Ishibashi

Yoshiyuki Murai

Tsuyoshi Mizutani

Kouzou Sawada

Noriko Oku

Kiyoshi Ikura

Naoki Kawada

Tomohiro Oku

Miho Kawauchi

Akira Katayama

Tomohito Oku, Legal Representative

Chikako Oku

Tomohito Oku

Kunihiko Dohtsu

Noriko Oku, Legal Representative

Noritsugu Yamazaki

Chikako Oku, Legal Representative

Chikaka Oku

Imidazole compounds represented by general formula (I): wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided. These compounds are useful in treating the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy inhibitory action.

Imidazole compounds and medicinal use thereof

A sulfonamide compound of the formula (I):R&#x2014;SONHCO&#x2014;A&#x2014;X&#x2014;R&#x2003;&#x2003;(I)wherein Ris alky, alkenyl, alkynyl and the like; A is an optionally substitutedheteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyland 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and Ris optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.

Sulfonamide compounds and pharmaceutical use thereof

The present invention relates to a sulfonamide compound of the formula (I):wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

Sulfonamide compounds and uses thereof as medicines

The present invention provides novel benzimidazole derivatives of the following formula (I) and salts thereof:wherein Rrepresents a lower alkyl group or a lower alkyloxy-lower alkyl group; Rrepresents a hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atoms, an aryl group, and such; Rrepresents a lower alkyl group, a lower alkenyl group, an aryl group, a lower alkylaryl group, an aryl-lower alkenyl group, a halothienyl group, a lower alkylamino group, or an aryl-lower alkylamino group; A represents a benzene ring, a naphthalene ring, or a pyridine ring; and X represents a halogen atom. The derivatives and their salts have blood sugar level-depressing activity or PDE5-inhibiting activity, and are useful as pharmaceutical preparations.

Benzimidazole derivatives

3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide, a compound having hypoglycemic activity or PDE5 inhibitory effect, has three forms of crystal forms that are distinguishable by their X-ray powder diffraction values. The most crystallographically stable crystal form is useful as a drug substance for medicines. Another crystal form can be purified efficiently by crystallization, since it forms larger crystals and can be very easily isolated by filtration. Thus this crystal form is useful for purifying 3-(2,4-Dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide.

Crystal forms of 3-(2,4-dichlorobenzyl)-2-methyl-n-(pentylsulfonyl)-3h-benzimidazole-5-carboxamide

Benzimidazole compounds

Sulfonamide compounds and medicinal use thereof

Novel aromatic ring derivatives represented by formula (I) or their pharmaceutical acceptable salts are provided.

Aromatic ring derivatives

Process for producing optically active triazole compounds and method of

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Niigata, Japan

Takafumi Imoto