Reverse Proteomics Research Institute Co., Ltd.

Astellas Pharma Gmbh

Takaaki Shiyama

Akito Tanaka

Akira Yamazaki

Tomohiro Terada

Masayuki Haramura

Tsuruki Tamura

Minoru Furuya

A resin which is prepared by polymerizing a monomer component incorporating a hydrophilic spacer, and a ligand-immobilized solid phase carrier obtained by immobilizing a ligand to the resin, are capable of reducing the non-specific adsorption of substances, other than the target molecule for the ligand, which mingle in the sample, to the resin and/or the ligand. Therefore, target molecule search, identification and the like with less noise are enabled.

Affinity resin

The present invention provides a method of suppressing the nonspecific interaction between molecules, characterized in that in a process to immobilize a molecule onto a solid phase carrier and analyze the specific interaction between the molecule and a molecule that specifically interacts with the molecule on the solid phase, the hydrophobic property of the solid phase surface in the solid phase carrier is regulated, particularly a hydrophilic spacer is interlaid at the time of immobilization of the molecule onto the solid phase carrier, which method makes it possible to suppress the nonspecific interaction between the molecules, and to reduce nonspecific adsorption to the solid phase.

Method of inhibiting nonspecific interaction between molecules on solid phase support

Growing community of inventors

Osaka, Japan

Takaaki Shiyama