Bayer Schering Pharma Ag

Bayer Aktiengesellschaft

Takaaki Nishioka

Roland Rupp

Venkata-Rangarao Kanikanti

Jan-Olav Henck

Yoshifumi Katakawa

Chika Taniguchi

Hitoshi Ichihashi

Wolfgang Weber

Peter Deuringer

Andreas Ohm

Helmut Luchtenberg

Heino Stab

Josef Schmoll

Manfred Bucheler

Eduard Porges

Ulrich Tenter

Haruo Kanasaki

Kenji Kuratani

Heino Staβ

The present invention relates to an orally administrable preparation comprising a quinolone antibiotic which releases the active compound with a delay.

Sustained-release preparations of quinolone antibiotics

Method of preparing sustained-release preparations of quinolone antibiotics

Sustained-release preparations of quinolone antibiotics and method for preparation thereof

This invention provides a long-lasting release solid nifedipine preparation which exhibits clinically sufficient effect when administered once per day. A press coated tablet whose core and shell each contains nifedipine, the dissolution rate of nifedipine from said tablet being (a) in the dissolution test using a sinker according to method 2 of the dissolution test method as prescribed by the Pharmacopoeia of Japan, after 2 hours 10-40% after 4 hours 30-65% after 6 hours at least 55%, and (b) in the dissolution test according to the disintegration test method as prescribed by the Pharmacopoeia of Japan, after 3 hours 20-45% after 4 hours 30-65%.

Long-lasting release nifedipine preparation

A pharmaceutical formulation tablet with a long-lasting action for 1 to 2 daily doses having a diameter between about 0.5 and 15 mm and comprising

Dihydropyridine depot formulation

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Nabari, Japan

Takaaki Nishioka