Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Takaaki Nishikiori

Hamao Umezawa

Tomio Takeuchi

Masa Hamada

Takaaki Aoyagi

Hiroshi Naganawa

Yasuhiko Muraoka

Plipastatin represented by the general formula ##STR1## wherein R.sub.1 is --C.sub.13 H.sub.27 or --C.sub.14 H.sub.29 ; and R.sub.2 is Ala or Val, or salts thereof, which is prepared by culturing a Plipastatin-producing strain belonging to the genus Bacillus to produce and accumulate Plipastatin in a cultured broth and then isolating Plipastatin from the cultured broth. Plipastatin exhibits an enzyme inhibiting activity against phospholipase A.sub.2, C and D and which will be useful as an immunosuppressive agent or as a type I anti-allergic agent.

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Tokyo, Japan

Takaaki Nishikiori