Nippon Kayaku Kabushiki Kaisha

Takaaki Nishikiori

Seiichi Saito

Takashi Harada

Masanori Yamazaki

Nobuyoshi Shimada

Kiyonobu Hirose

Tomio Morino

Takashi Kurokawa

Akira Masuda

Masashi Nagai

Tsugio Tomiyoshi

Takamichi Sato

Masakazu Nishimoto

Takumi Yamashita

Eiji Kawano

Masatoshi Yamada

Atsushi Kuwahara

Mituyuki Nishide

Takumi Yamshita

Takako Tsuchiya

A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.

Compound having effect of promoting neuron differentiation

Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3 having antibacterial, antineoplastic, immunomodulation, and liver regeneration promoting activities are provided. NK374186A, NK374186B, NK374186B3 and NK374186C3 are obtained by culturing NK374186 strain (FERM P-12285) (FERM-BP 3870) belonging to the genus Penicillium. NK374186A is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.12 S.sub.9 and having a molecular weight of M+ 735 (FD-MS m/z); NK374186B is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); NK374186B3 is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); and NK374186C3 is a compound represented by a rational formula of C.sub.32 H.sub.59 N.sub.3 O.sub.7 and having a molecular weight of M+ 597 (FD-MS m/z).

Antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3, process for

This invention relates to an antibiotic NK86-0279 of the formula: ##STR1## which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.

Antibiotic NK86-0279, process for production of the same and application

This invention relates to an antibiotic NK130119 of the formula: ##STR1## which exhibits antifungal, antitumor, vascularizations-inhibitory and insecticidal activities.

Novel antibiotic NK130119

Growing community of inventors

Yono, Japan

Takaaki Nishikiori