Santen Pharmaceutical Co., Ltd.

Singapore Health Services Pte Ltd

Takaaki Inaba

Minoru Yamamoto

Kenji Kawashima

Hiroshi Enomoto

Kazuyoshi Okamoto

Masaaki Murai

Kazuhiro Kudou

Noriko Ishizaka

Takahiro Honda

Masatomo Kato

Hisashi Tajima

Roger Wilmer Beuerman

Tiang Hwee Donald Tan

Yuriko Takeno

Aradhana Upadhyay

Seang-Mei Saw

The present invention relates to an agent for preventing myopia, treating myopia, and/or preventing myopia progression, comprising tiotropium as an active ingredient.

Agent for preventing myopia, treating myopia, and/or preventing myopia progression comprising tiotropium as active ingredient

Disclosed is a compound represented by the general formula (1) or a salt thereof. The compound or a salt thereof has an inhibitory activity on IKK&#x3b2; and is therefore useful as preventive and/or therapeutic agent for a disease associated with IKK&#x3b2;. In the formula, Rrepresents a hydrogen atom, a lower alkyl group, an aryl group, a hydroxy group, or the like; Rrepresents a halogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, or the like; and m represents 0, 1, 2, or the like. 

Indole derivative having I&#x3ba;B kinase &#x3b2; inhibitory activity

Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; Rrepresents a halogen atom, a hydrogen atom, a lower alkyl group or the like; Rrepresents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like. 

Pyrrole derivative having ureido group and aminocarbonyl group as substituents

A novel cyclic compound having a 4-pyridylalkylthio group having an (un)substituted amino group introduced therein or a salt thereof. They are useful as a medicine. The cyclic compound is a compound represented by the following formula (1), which is useful for the treatment of diseases in which angiogenesis participates. In the following formula (1), ring A represents a benzene ring or a 5- or 6-membered aromatic heterocycle optionally fused with a cycloalkane ring; B represents alkylene; Rand Reach represents H, (substituted) aryl, (substituted) heterocyclic group, etc.; Rand Reach represents H, (substituted) alkyl, (substituted) cycloalkyl, -Z-R, etc.; Rrepresents (substituted) alkyl, (substituted) aryl, (substituted) heterocyclic group, etc.; X and Y each represents H, etc.; Z represents &#x2014;CO&#x2014;, &#x2014;COO&#x2014;, &#x2014;CONR&#x2014;, &#x2014;SO&#x2014;, etc.; Rrepresents H, etc.; p is 0, 1, or 2; and q is 0 or 1. 

Cyclic compound having 4-pyridylalkylthio group having substituted or unsubstituted amino group introduced therein

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Ikoma, Japan

Takaaki Inaba