Bristol-Myers Squibb Compnay

E. R. Squibb Sons, Inc.

Tak-lung Chang

Agis F Kydonieus

Kishore R Shah

Sheng-hung Kuo

Khosrow Jamshidi

Stefanie C Decker

Ladislav Bastar

Method for forming a polyurethane based adhesive composition in which a reaction mixture of at least one NCO-terminated prepolymer and a polyhydroxy compound is heated at a temperature and for a length of time sufficient to provide a gel content of from about 30 to 42% by weight and a molecular weight of extractables of at least about 45,000. Polyurethane based adhesives prepared by the method and medical devices employing the same are also disclosed.

Polyurethane pressure-sensitive adhesives

In accordance with the present invention novel polyurethane PSAs containing water soluble polymer additives have enhanced water uptake. The water soluble polymer additives suitable for use herein have a solubility parameter in poorly hydrogen-binding solvents (e.g., hexane, cyclohexane and the like) in the range of from 8-10. The water soluble polymers must also be free from moieties which will react with isocyanates. Such PSAs retain their transparency and peel strength characteristics and can still be employed as relatively thin films (i.e., 2 to 100 mils) while exhibiting only minimal swelling when in contact with moist environments.

Water soluble polymer additives for polyurethane-based pressure

Pressure-sensitive adhesives which possess absorptivity and/or permeability properties to remove transepidermal water loss and/or other bodily fluids that come into contact with the adhesive, in combination with a fine balance of cohesion and adhesion properties, can be formulated by controlling the crosslinking of a polyurethane polymer having excess hydroxyl functionality, a glass transition temperature of less than about 0.degree. C., a moisture absorption of at least about 20% of its weight and/or a moisture vapor transmission rate of at least about 300 grams/meter.sup.2 /24 hours measured at 37.degree. C. and a 90% relative humidity gradient. Adhesives of these polymers possess a peel adhesion to human skin of between about 0.3 and 4 newtons/cm width of the polymer or adhesive.

A composite material for wound dressings having a fibrous wound-contacting substrate, such as cotton gauze, impregnated with a thermoplastic hydrogel forming polymer and methods of making the same.

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Skillman, NJ, United States of America

Tak-lung Chang