Kaneka Corporation

Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Taizo Kawabe

Kenji Fujii

Takayoshi Hidaka

Kazunori Hosoe

Yoshihide Fuse

Ikuo Katsumi

Keiji Kameyama

Toshiaki Miwa

Yasuyoshi Ueda

Takahiro Ueda

Shiro Kitamura

Hideyuki Kishida

Hiroshi Kubo

Hozumi Tanaka

Airo Tategaki

Yoji Hisada

Naoko Yasuhara

This invention provides lactic acid bacteria that have one or more effects selected from among fatigue-ameliorating effect, blood circulation-improving effect, stool odor-reducing effect, and growth-promoting effect and that can be used with high safety. This invention further provides a pharmaceutical preparation comprising, as an active ingredient, lactic acid bacteria that have one or more effects selected from among fatigue-ameliorating effect, blood circulation-improving effect, stool odor-reducing effect, and growth-promoting effect. According to the invention, novel lactic acid bacteria belonging to thespecies having particular mycological properties and exhibiting viability of 40% or higher when freeze-dried in the absence of a dispersion medium and viability of 80% or higher in a probiotic preparation when stored at 40&#xb0; C. for 4 months, a composition comprising such lactic acid bacteria, an agent for ameliorating fatigue, improving blood circulation, reducing stool odor or promoting growth comprising, as an active ingredient, such composition, and use of such composition for food and other products.

Lactic acid bacterium

To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.

Fatigue reducing agent

The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having swallowing difficulties and patients with diseases caused by topical disorders. It is found that the coenzyme Q concentration in the blood or topical mucosae can be elevated by using a composition for transmucosal administration containing oxidized coenzyme Q and/or reduced coenzyme Q as the active ingredient, wherein the total content of the oxidized coenzyme Q and the reduced coenzyme Q amounts to 0.0001 to 99% by weight of the whole composition.

Composition for transmucosal administration containing conenzyme Q as the active ingredient

The object of the present invention is to provide a composition maintaining a blood coenzyme Q concentration at a high level in blood for a prolonged period of time, in order to surely attain an effect of coenzyme Q, which can be expected to manifest a superior effect in maintaining health in humans and animals. By using a composition which comprises a coenzyme Q being a mixture of a reduced coenzyme Q and an oxidized coenzyme Q with the proportion of the reduced coenzyme Q to the whole coenzyme Q of more than 95% by weight, the present invention can attain a high maximum blood concentration of a coenzyme Q as well as long maintenance of high concentration of coenzyme Q in blood for a prolonged period of time, and the area under the blood concentration curve (AUC) can be expanded.

Coenzyme Q compositions persisting in blood

The present invention provides a reduced coenzyme Q-containing solution capable of being retained more stably against oxidation, by using a reduced coenzyme Q which is hydrophobic and susceptible to oxidation and thus unstable. The aqueous solution containing a reduced coenzyme Q obtained in the present invention is a solution containing a reduced coenzyme Q and an antioxidant such as vitamin C and/or a chelating agent such as ethylenediaminetetraacetic acid.

Stabilized compositions of aqueous reduced coenzyme Q solution

The present invention provides a reduced coenzyme Qcrystal with excellent stability and a composition containing said reduced coenzyme Qcrystals. According to the present invention, after dissolving reduced coenzyme Qin a fat and oil, it is cooled, making it possible to obtain reduced coenzyme Qcrystals with excellent stability and which exhibit an x-ray diffraction pattern (using a CuK&#x3b1; emission line) that differs from ordinary reduced coenzyme Qcrystals. Moreover, said crystals are also excellent in bioabsorbability.

Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal

The present invention provides an antioxidative composition with high safety, which is capable of lessening oxidative stress due to active oxygen species, free radicals, or the like in vivo, thereby preventing the occurrence or worsening of a disease. It was confirmed that by using a composition containing oxidized coenzyme Q and/or reduced coenzyme Q, the amount of urinary 8-hydroxydeoxyquanosine can be decreased in normal or diabetic animals. Also, in histopathological research of the spleens of diabetic rats, it was confirmed that spleen tissue denaturation caused by oxidative stress can be prevented. It was thus found that oxidative stress in vivo can be lessened. According to the present invention, oxidative stress in vivo can be lessened by using a composition containing coenzyme Q as an active ingredient.

Compositions for lessening oxidative stress

The present invention has for its object to provide a method and a composition for achieving a more efficient recovery of the antioxidant activity of plasma LDL, or even augmentation thereof, which has been depressed by the use of an antihyperlipidemic or cholesterol-lowering drug to thereby insure a potentiated antiarteriosclerotic efficacy. A method for inhibiting arteriosclerosis, which comprises using a combination of a cholesterol-lowering agent and a reduced coenzyme Qrepresented by the following formula (1), and a composition for inhibiting arteriosclerosis containing both a cholesterol-lowering agent and said reduced coenzyme Q.

Method and composition for inhibiting arteriosclerosis

Livestock and poultry are fed with feed containing at least one spice chosen from among the families Myristicaceae, Cruciferae, Rutaceae, Compositae, Pedaliaceae, Piperaceae, Leguminosae, Umbelliferae, Myrtaceae, Solanaceae, Labiatae, Lauraceae, Liliaceae and Zingiberaceae, whereby the active ingredients of the spice taken into the bodies of the thus-fed livestock and poultry are transferred to their internal fat thereby to modify their meat and to improve the smell of their fat. Accordingly, the fatty smell of the meat and fat to be obtained from the thus-fed livestock and poultry is removed and the freshness-keeping power of the meat and fat is enhanced. As the spices may be added to feed, livestock and poultry may efficiently take the spices with ease.

Feed for livestock and poultry and a method for improving meat and fat

Cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from the group consisting of the above-mentioned cinnamamide derivative and the pharmaceutically acceptable salt thereof.

Cinnamamide derivative

Novel cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from the group consisting of the above-mentioned cinnamamide derivative and the pharmaceutically acceptable salt thereof.

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Takasago, Japan

Taizo Kawabe