Toray Industries, Inc.

Taisuke Hirano

Masakazu Koiwa

Kenzo Fujimoto

Nobuo Ida

Yoji Ueda

Fumio Nakamura

Reiji Nishio

Yoshinori Kakizawa

Yoichiro Koshi

Junji Michizoe

A method of detecting a target nucleic acid by sandwich hybridization using a detection probe that hybridizes with the target nucleic acid, and a capture probe immobilized on a support wherein at least one nucleic acid base in the nucleic acid molecule(s) of the detection probe and/or capture probe with a photoreactive group includes irradiating, with light, a complex formed by hybridization between the target nucleic acid and the detection probe and/or capture probe to allow formation of a covalent bond(s) between the photoreactive group(s) and a nucleic acid base(s) in the target nucleic acid.

Method of detecting target nucleic acid

A microparticle includes an agglomerate of a hydrophilic active substance containing particle, which particle includes an amphiphilic polymer composed of a hydrophobic segment of poly(hydroxy acid) and a hydrophilic segment of polysaccharides or polyethylene glycol, and a hydrophilic active substance. It is characterized by an efficient inclusion of the hydrophilic active substance, and a release of the hydrophilic active substance at an appropriate speed in the human body, and is hence very useful as a DDS pharmaceutical preparation.

Microparticle and pharmaceutical composition thereof

Growing community of inventors

Kamakura, Japan

Taisuke Hirano