Nippon Shinyaku Company, Ltd.

Taisuke Hamamoto

Tetsuo Asaki

Keiichi Kuwano

Yukiteru Sugiyama

The present invention provides an amide derivative represented by the following general formula (1): wherein Rrepresents a saturated cyclic amino group, Rrepresents alkyl, halogen or haloalkyl, Rrepresents hydrogen or halogen, Het 2 represents pyridyl or pyrimidinyl, and Het 1 represents a group of the formula [6], or a salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.

Amide derivative

The present invention provides a compound which is useful as a PGIreceptor agonist, and a pharmaceutical composition. The present invention is directed to a pharmaceutical composition comprising a compound represented by the following formula [1]: (Rand Rare the same or different and each represents optionally substituted aryl, Y represents N or CH, Z represents N or CH, A represents NH, NR, O, S, or ethylene, Rrepresents alkyl, D represents alkylene or alkenylene, E represents phenylene or single bond, G represents O, S, or CH, Rand Rare the same or different and each represents hydrogen or alkyl, Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, or N-(alkylsulfonyl)carbamoyl), or a pharmaceutically acceptable salt thereof as an active ingredient.

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Matsubara, Japan

Taisuke Hamamoto