U.S. Patent Innovations, LLC

Jerome Canady Research Institute for Advanced Biological and Technological Sciences

Washington University

Jerome Canady Research Institute

U.S. Medical Innovations Lls

Jerome Canady Research Institute for Advanced Bio

Taisen Zhuang

Jerome Canady

Feng Yan

Xiaoqian Cheng

Michael Keidar

Alexey Shashurin

Saravana Murthy

Megan O'Connell

Dereck Chiu

Daniel Tabatabai

Buddika Sumanasena

Tse Huai Wu

Evgueni Sokolovski

Alice Chang

Aditya Shanghavi

Shruti Wigh

Tanner Pierce

Cheffran Canady

Charlesa Humphrey

Laxmi Ray

Omar Dary

Jerome McQueen

George Lewis Teel

Zhangshi Liu

Siddhant Chawla

Cheffren Canady

Changhan Jun

Saravana R K Murthy

Olivia Jones

Alexy Shashurin

Arpitha Parthasarathy

Yan Feng

Ronald Govoro

Lawan Ly

Jerome Md Canady

A method for bioengineering exosomes for cancer treatment. The method comprises the steps of isolating target tumor cells from a tissue sample, culturing the isolated target tumor cells, treating the cultured target tumor cells with cold atmospheric plasma to release exosomes from the target tumor cells, and collecting the released exosomes. The step of culturing the target tumor cells may comprise seeding the isolated target tumor cells in wells and incubating the target tumor cells in a culture media, for example, for 24 hours. The culture media may comprise Dulbecco's Modified Eagle Medium, an antibiotic and 10% fetal bovine serum. The step of culturing the target tumor cells may further comprise replacing the culture media with Dulbecco's Modified Eagle Medium and an antibiotic. The target tumor cells may comprise, for example, one of U87 cells, KKU-055 cells and triple negative MDA-MB-231 cells.

Method for cold atmospheric plasma exosome therapy

A method for a method for treatment of cholangiocarcinoma (CCA) with cold atmospheric plasma and Folfirinox. The method includes treating a patient having CCA with a low dosage FOLFIRINOX regimen, for example, 6.73 nM, giving the patient the low-dosage FOLFIRINOX regimen pre-operatively, surgically removing the cancerous tumor from the patient, continuing the low-dosage FOLFIRINOX treatment regimen intra-operatively, applying cold atmospheric plasma to the surgical margins surrounding the area in the patient from which the tumor was removed, and continuing the FOLFIRINOX post-operatively.

Method for treatment of cholangiocarcinoma with cold atmospheric plasma and folfirinox

A method for applying cold atmospheric plasma treatment to target tissue comprising the steps of treating a patient with a pharmaceutical for suppressing apolipoprotein E genes, selecting through a graphical user interface a particular soft tissue sarcoma cell line associated with target tissue, retrieving, with the computing device, settings data associated with the selected soft tissue sarcoma cell line from a database of cell line data and associated settings data in a storage, and applying, with the computing device, the retrieved settings data to a cold atmospheric plasma system.

System and method for suppressing apoe gene for sarcoma treatment

A method for inducing cell death in breast cancer regardless of subtyping through histone mRNA oxidation and degradation during the early S-phase of the cell cycle. A method for monitoring levels of oxidized histone mRNA in breast cancer cells, comprising the steps of isolating histone mRNA from breast cancer cells, incubating the histone mRNA with a peptide according to SEQ ID NO: 1 and determining the levels of oxidized histone mRNA by measuring the fluorescence intensity.

Method for cold plasma induced cell death in breast cancer cells by 8-oxoG modification and degradation of histone mRNA

A method for treating cancer. The method comprises treating a patient having a cancerous tumor with a gene inhibitor pre-operatively to inhibit upregulation of a particular gene, surgically removing the cancerous tumor, treating the patient with the gene inhibitor intra-operatively to inhibit upregulation of a particular gene, applying cold atmospheric plasma to surgical margins around the area in the patient from which the tumor was surgically removed, and treating the patient with the gene inhibitor post-operatively.

Method for treatment of cancer with combination of cold atmospheric plasma and a gene inhibitor

A system and method for voice control of operating room electrical equipment. The system comprises an electrosurgical generator a controller with a memory, a graphical user interface controlled by said controller, a power module, a field programmable gate array, and a voice recognition module connected to said field programmable gate array, a data storage connected to said controller in said electrosurgical generator; and electrical operating room equipment connected to said voice recognition module, wherein said electrical operating room equipment is configured to receive and decrypt encrypted commands from said voice recognition module. The electrical operating room equipment may said electrosurgical generator or a robotic surgical system or other electrical equipment in an operating room. The connection between said electrical operating room equipment and said voice recognition module may be wireless. The connection between said data storage and said controller in said electrosurgical system also may be wireless.

System and method for voice-control of electrosurgical system

A method for applying cold atmospheric plasma treatment to target tissue comprising the steps of selecting through a graphical user interface a particular soft tissue sarcoma cell line associated with target tissue, retrieving, with said computing device, settings data associated with said selected soft tissue sarcoma cell line from a database of cell line data and associated settings data in a storage, and applying, with said computing device, said retrieved settings data to a cold atmospheric plasma system.

System and method for combination of cold atmospheric plasma treatment with radiation and chemotherapy

An integrated gas-enhanced electrosurgical generator. The generator comprises a high frequency power module, a low frequency power module and a gas module. The high frequency power module adapted to generate an electrical energy having a band of frequencies centered around a first frequency, wherein the electrical energy has a first power as the first frequency and a second power lower than the first power at a second frequency lower than the first frequency. The low frequency power module having an input connected to an output of the high frequency module. The low frequency module comprises a resonant transformer comprising a ferrite core, a primary coil and a secondary coil, the secondary coil having a larger number of turns than the primary coil, wherein the resonant transformer has a resonant frequency equal to the second frequency. The gas module is adapted to control a flow of an inert gas.

Integrated cold plasma and high frequency plasma electrosurgical system and method

An attachment for a gas-assisted electrosurgical device. The attachment has a housing having a channel within it, an electrosurgical blade and an electrical connector. The electrosurgical blade has a conductive member comprising an elongated distal portion and a proximal portion, the distal portion having a width greater than a width of the proximal portion, the width of the distal portion being at least three times the thickness of the distal portion, and a coating on at least a portion of said conductive member.

Attachment for electrosurgical system

A method for performing cold atmospheric plasma treatment of respiratory infections or lung cancer having a source of a carrier gas, a cold atmospheric plasma generator connected to the source of carrier gas, a source of compressed air, a humidifier connected to the source of compressed air, a source of oxygen, a ventilator having inputs connected to an output of the humidifier and the source of oxygen, a mixer having an interior chamber formed from a dielectric, an active electrode inside the interior chamber, and an outer electrode connected to ground, wherein the mixer has a fluid input port connected to a gas output of the cold atmospheric plasma generator and an output of the ventilator, and a delivery member connected to an output of the mixer for delivering combined humidified air and cold atmospheric plasma to a respiratory system of a patient.

Method for treatment of respiratory infections and cancers of the respiratory system using cold atmospheric plasma

A configurable electrosurgical generator front panel. The configurable electrosurgical generator front panel has a front panel frame, a display screen or tablet computing device, and a plurality of connectors for connecting accessories to the front panel frame. The front panel in the front panel assembly provides a novel structure for inserting a screen or tablet device into the front panel frame and securing it in place.

Configurable electrosurgical generator housing

A method for treating cancer by treating target cancer cells with cold atmospheric plasma to induce apoptosis of the target cancer cells through the degradation of Histone RNA during S-phase induced by oxidation of RNA.

Cold atmospheric plasma therapy to treat cancer

A cold plasma accessory having a hand piece having within in it flexible tubing, wiring, a PCB board connected to the wiring, and a conductive connector tube electrically connected to the PCB board, the conductive connector tube having an inner channel, a rigid tube extending from the distal end of the hand piece, and an electrode within the rigid tube. The electrode comprises a conductive connector having a contact surface contacting the conductive connector tube, a distal end surface facing away from the conductive connector tube, and a channel extending through a center of the conductive connector, the channel being fluidly connected to the flexible tubing, the distal end surface of the conductive connector being outside of the channel in the conductive connector, and a conductive wire connected to the distal end surface of the conductive connector.

Plasma accessory

A gas-enhanced electrosurgical generator. The gas-enhanced generator has a housing, a first gas control module in the housing and configured to control flow of a first gas, a second gas control module in the housing and configured to control flow of a second gas, a high frequency power module, and a controller, processor or CPU within the housing and configured to control the first gas control module, the second gas control module and the high frequency power module. The first gas and second gas may be any of CO, argon and helium or another gas. The gas-enhanced electrosurgical generator may have a third gas control module in the housing and configured to control flow of a third gas and a third connector secured on an exterior of the housing.

Gas-enhanced electrosurgical generator

Display screen with a graphical user interface

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Rockville, MD, United States of America

Taisen Zhuang