Kaken Pharmaceutical Company, Ltd.

Basotherm Gmbh

Kakenyaku Kako Kabushiki Kaisha

Taira Okamoto

Tsutomu Nakamura

Motoyuki Yajima

Hiroshi Yamamoto

Michio Ui

Shigeki Kurokawa

Katsumi Nogimori

Mitsuru Watanuki

Toshihiro Koyama

Masanao Shimano

Akio Terashima

Masaru Ogawa

Chikanori Tomioka

Koichi Hosoda

Satoshi Murai

Toshimitsu Hori

Isamu Takahashi

Yoshinori Kanbayashi

Akira Ito

A piperidine derivative having the formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different from each other, are (i) a not-substituted phenyl group or a phenyl group substituted by a halogen atom, trifluoromethyl group, a C.sub.1-5 alkyl group or a C.sub.1-5 alkoxyl group, (ii) a C.sub.3-7 cycloalkyl group, (iii) pyridyl group or (iv) thienyl group, R.sup.3 is (i) hydrogen atom, (ii) a halogen atom, (iii) a C.sub.1-4 alkyl group or (iv) a C.sub.1-4 alkoxyl group, R.sup.4 is (i) hydrogen atom or (ii) a C.sub.1-4 alkyl group. R.sup.5 is (i) a not-substituted C.sub.1-5 alkyl group or a C.sub.1-5 alkyl group substituted by a halogen atom, (ii) phenyl group or (iii) thienyl group and Z is (i) a C.sub.1-6 alkylene group, (ii) a C.sub.2-6 alkenylene group or (iii) a C.sub.3-6 alkynylene group or a pharmacologically acceptable salt thereof. According to the present invention, an anti-allergic agent and a therapeutic agent for ischemic heart disease without toxicity can be provided.

Piperidine compounds which have useful pharmaceutical activity

Disclosed are novel opthalmic solutions useful for the treatment of ocular hypertension and glaucoma. These contain mabuterol as a preferred active ingredient.

Ophthalmic solution for intraocular pressure adjustment

Novel biologically active substances prepared by dissociating the protein obtained from the cultivation of the microorganism Bordetella and having insulin secretion promoting action as well as glucose tolerance improving action for mammals.

Proteinic active substances

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Otsu, Japan

Taira Okamoto