Legend Biotech Ireland Limited

Tailan Zhan

Shu Wu

Qing Zhang

Yafeng Zhang

Jian Liu

Wang Zhang

Yun Zhang

Xiaojie Tu

Yunlei Liu

An Tang

Fei Sun

Chenyu Shu

The present application provides single-domain antibodies targeting CD33 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune cells (such as T cells) comprising an anti-CD33 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Single-domain antibodies against CD33 and constructs thereof

Provided are single-domain antibodies targeting CLL1 and constructs thereof, including chimeric receptors, immune effector cell engagers and immunoconjugates. Further provided are engineered immune effector cells (such as T cells) comprising an anti-CLL1 chimeric receptor and optionally a second chimeric receptor targeting a second antigen or epitope. Pharmaceutical compositions, kits and methods of treating cancer are also provided.

Single-domain antibodies against CLL1 and constructs thereof

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Jiangsu, China

Tailan Zhan