Eisai R&d Management Co., Ltd.

Eisai Company, Limited

Taiju Nakamura

Yusuke Ayata

Taichi Abe

Hirofumi Kuroda

Atsushi Akao

Yusuke Miyashita

Shigeto Negi

Kazuhiro Yoshizawa

Hiroyuki Chiba

Akio Kayano

Shin Sakurai

Hiroyuki Ishizuka

Hiroyuki Saito

Nobuaki Sato

Yasuyuki Suzuki

Tomohiro Matsushima

Atsushi Kamada

Kazuhide Ashizawa

Manabu Sasho

Masahiko Tsujii

Takahisa Sakaguchi

Itaru Arimoto

Masaharu Gotoda

Takako Yoshiba

Ikuo Kushida

Masahiro Sakurai

Eiichi Yamamoto

Yuuki Komatsu

Naoko Suzuki

Astsushi Koiwa

Kazuhiro c/o Eisai Co Ltd Yoshizawa

Itaru c/o Eisai Co Ltd Arimoto

Yusuke c/o Eisai Co Ltd Ayata

Provided is a compound represented by formula (IV) or a salt thereof, wherein the content of the compound represented by formula (I) is 350 ppm by mass or less. 

High-purity quinoline derivative and method for manufacturing same

A crystal of a 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide hydrochloride, hydrobromide, p-toluenesulfonate, sulfate, methanesulfonate or ethanesulfonate, or a solvate thereof.

Crystalline form of the salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide or the solvate of the salt and a process for preparing the same

The present invention relates to a method for producing an isoindole derivative (compound (II)) with the following general formula (II): (wherein Rand Reach independently represents a Calkyl group) or a salt thereof, comprising the step of cyclizing, in a solvent, compound (I) with the following general formula (I): (wherein Rand Rhave the same meanings as Rand Rin formula (II) above) or a salt thereof, or their hydrate or solvate in the presence of a base (Step 1).

Methods for producing isoindole derivatives

The present invention provides carbapenem hydrochloride trihydrate crystals, which are chemically stable, easily purified and useful as antimicrobial agents, a process for producing them, and a powdery charged preparation for injection containing them. That is, it provides carbapenem hydrochloride trihydrate crystals having a powdery X-ray diffraction pattern containing lattice distances (d) of 9.0, 4.1 and 2.8 &#x212b;, a process for producing them, and a powdery charged preparation for injection containing them.

Carbapenem compound crystals and interjection preparations

Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates

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Kamisu, Japan

Taiju Nakamura