Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Taihei Yamane

Takashi Sohda

Hiroyuki Tawada

Masaki Ogino

Atsuo Baba

Haruhiko Makino

Yoshihiro Banno

Satoru Oi

Koji Ikedou

Atsushi Inagaki

Koji Takeuchi

Osamu Yabe

The present invention provides a compound of the formula: wherein ring A is an optionally substituted 5 to 10-membered aromatic ring; Rand Rare the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond and the like; and L is a divalent hydrocarbon group, and a salt thereof, except 3-(aminomethyl)-2,6,7-trimethyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-2-methyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-6-chloro-2-methyl-4-phenyl-1(2H)-isoquinolinone and 3-(aminomethyl)-2-isopropyl-4-phenyl-1(2H)-isoquinolinone. The compound shows a superior peptidase-inhibitory activity and is useful as an agent for the prophylaxis or treatment of diabetes and the like.

Fused heterocyclic compounds

The present invention provides, as an industrially advantageous production method, a method of producing a compound represented by the formula (III)

Process for the preparation of oxyiminoalkanoic acid derivatives

Thienodipyridine derivatives, production and use thereof

Growing community of inventors

Takarazuka, Japan

Taihei Yamane