Takasago International Corporation

Taichiro Touge

Shigeru Tanaka

Kenya Ishida

Hideki Nara

Tomohiko Hakamata

Tomohiko Hakamada

Takahiro Fujiwara

Wataru Kuriyama

Kunimori Aoki

The present invention pertains to a method for producing an optically active compound which includes a step for reducing an imino group of an imine compound or a step for reducing an unsaturated bond of a heterocyclic compound, while in the presence of hydrogen gas as a hydrogen donor and one or more types of complexes selected from a group consisting of a complex represented by general formula (1), a complex represented by general formula (2), a complex represented by general formula (3), and a complex represented by general formula (4) (the general formulas (1)-(4) are as stipulated by claim).

Method for producing optically active compound, and novel metal-diamine complex

Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein Rrepresents an alkyl group or the like; Y represents a hydrogen atom; X represents a halogen atom or the like; j and k each represent 0 or 1; Rand Reach represent an alkyl group or the like; Rto Reach represent a hydrogen atom, an alkyl group or the like; Z represents oxygen or sulfur; nrepresents 1 or 2; and nrepresents an integer from 1 to 3, a method for producing the ruthenium complex, a catalyst for asymmetric reduction formed from the ruthenium complex, and methods for selectively producing an optically active alcohol and an optically active amine using the catalyst for asymmetric reduction. 

Ruthenium-diamine complexes and method for producing optically active compounds

The present invention relates to a diamine compound represented by the general formula (1), a ruthenium-diamine complex, an iridium-diamine complex, and a rhodium-diamine complex having the diamine compound as a ligand. Furthermore, the present invention relates to methods for selectively producing optically active compounds by using any of these complexes as a catalyst. 

Diamine compound and metal complexes, and method for producing optically active compounds

The present invention provides a method for producing a compound represented by general formula (1) (wherein R, R, R, R-R, A-A, nand nare as defined in the description), which is characterized by reacting a compound represented by general formula (2) (wherein R-R, A-A, n, nand B are as defined in the description) with a diamine compound represented by general formula (3) (wherein R-Rare as defined in the description). The present invention is a method for producing a diamine compound, which is useful for the formation of a ruthenium-diamine complex, under mild conditions, said method being able to be put in industrial practice. 

Method for producing diamine compound

Provided by the present invention is a method for efficient oxidation of alcohols by using, as a catalyst for dehydrogenation oxidation, a ruthenium complex which can be easily produced and easily handled and is obtainable at a relatively low cost. The invention relates to a method of producing a compound having a carbonyl group by dehydrogenation oxidation of alcohols by using as a catalyst the ruthenium carbonyl complex represented by the following general formula (1) RuXY(CO)(L) (1) (in the general formula (1), X and Y may be the same or different from each other and represent an anionic ligand, and L represents a tridentate aminodiphosphine ligand).

Method for producing compound with carbonyl group by using ruthenium carbonyl complex having tridentate ligand as dehydrogenation oxidation catalyst

Provided is a ruthenium complex that is represented by general formula (1*) and is useful as an asymmetric reduction catalyst. (In the formula, * is an asymmetric carbon atom; Ris an arenesulfonyl group, and the like; Rand Rare a phenyl group, and the like; Rthrough Rare selected from a hydrogen atom, Calkyl group, and the like, but Rthrough Rare not simultaneously hydrogen atoms; X is a halogen atom and the like; j and k are each either 0 or 1; and j+k is 0 or 2.) 

Ruthenium-diamine complex and method for producing optically active compound

There are provided a ruthenium-diamine complex, and methods for selectively producing an optically active alcohol and an optically active amine, which are important as precursors for the synthesis of medicinal drugs and functional materials, using the ruthenium-diamine complex as a catalyst. The invention provides a ruthenium-diamine complex prepared by introducing a trisubstituted silyl group into an aromatic compound (arene) moiety that is coordinated with a ruthenium complex having an optically active diamine as a ligand, a catalyst for asymmetric reduction formed from the ruthenium-diamine complex, and a method for producing an optically active alcohol or an optically active amine using the catalyst.

Ruthenium-diamine complex and methods for producing optically active compounds

The present invention provides a novel method for simply and efficiently producing a ruthenium aromatic complex which is suitable also as an industrial method. The production method includes reacting a ruthenium aromatic complex with an aromatic compound as a ligand of the ruthenium aromatic complex, In a sealed reaction container at a reaction temperature higher than the boiling point of the aromatic compound to produce a ruthenium aromatic complex having, as a ligand, an aromatic compound having a lower boiling point.

Method for producing ruthenium complex

The present invention is to provide a ruthenium complex having a novel arene moiety, which has improved solubility in various solvents, and a method for production thereof. The present invention relates to a novel ruthenium complex having an arene moiety, which has a trisubstituted silyl group introduced to the arene moiety, and a method for production thereof.

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Hiratsuka, Japan

Taichiro Touge