Mitsubishi Tanabe Pharma Corporation

Taichi Takahashi

Daisuke Iijima

Hisayuki Takamatsu

Shuzo Takeda

Hiroyuki Satoh

Masakazu Fujio

Shinya Inoue

Koji Matsumoto

Toshifumi Matsumoto

Yasuhiro Egi

Akinori Umino

Shinji Kawata

Maki Niijima

A method for treating or preventing a disease involving autotaxin including administering a carboxylic acid compound of formula (1) or a pharmacologically acceptable salt thereof to a patient in need thereof.

3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same

Provided is a compound superior in an ATX inhibitory action and useful for the prophylaxis or treatment of diseases involving ATX. A carboxylic acid compound represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

Provided is a compound superior in an autotaxin inhibitory action and the like, effective as a prophylactic or therapeutic drug for diseases involving ATX. The present invention relates to a compound represented by the following formula (I): [wherein each symbol is as described in the DESCRIPTION], which has a superior autotaxin inhibitory action and is useful as a prophylactic or therapeutic drug for diseases involving ATX.

2-amino-pyridine and 2-amino-pyrimidine derivatives and medicinal use thereof

Provided is a heterocyclic derivative showing a thyroid hormone &#x3b2; receptor agonist action, which is effective for the prophylaxis or treatment of the diseases relating to the action. A compound represented by the formula [I]: wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, and a medicament containing the compound as an active ingredient.

Thyroid hormone &#x3b2; receptor agonist

The present invention relates to an isoquinoline compound represented by the following formula (I) or (II), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction. 

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Osaka, Japan

Taichi Takahashi