Chugai Seiyaku Kabushiki Kaisha

Tokyo Medical and Dental University

Tai Hirakura

Tsuyoshi Shimoboji

Kazunari Akiyoshi

Nobuyuki Morimoto

Takashi Nakai

Teruo Nakamura

Kenji Yasugi

Tomoko Yasugi

Yoshihiro Tampo

The present invention provides a hyaluronic acid derivative comprising disaccharide units of Formula (I), and a hyaluronic acid derivative/drug conjugate wherein one or more drugs are conjugated to the hyaluronic acid derivative.

Derivative of hyaluronic acid modified with amino-carboxylic acid

The present invention provides a composition comprising a hyaluronic acid derivative having a crosslinking group(s) and a hydrophilic polysaccharide derivative having a hydrophobic group(s), wherein the hyaluronic acid derivative having a crosslinking group(s) is prepared by crosslinkage formation reaction in hyaluronic acid or a derivative thereof having a crosslinkable group(s) in the presence of the hydrophilic polysaccharide derivative wherein the hydrophilic polysaccharide derivative may have a crosslinkable group(s).

Hybrid gel comprising chemically crosslinked hyaluronic acid derivative and  pharmaceutical composition comprising the same

The present invention provides a hydrophobic group-introduced hyaluronic acid derivative comprising at least one repeating unit represented by the formula (I): wherein R, R, R, R, Z, n, Ra, Y, and Xare as defined in the specification.

Hyaluronic acid derivative and pharmaceutical composition thereof

A hyaluronic acid modification product includes a polymer bonded to hyaluronic acid, the polymer being polylactic acid, polyglycolic acid or lactic acid-glycolic acid copolymer, providing a drug carrier which efficiently encapsulates low molecular weight drugs and provides sustained-release over a long term, control of blood residence, is well dispersible in an aqueous solution, and has excellent biocompatibility.

Growing community of inventors

Gotenba, Japan

Tai Hirakura