The United States of America, As Represented by the Secretary, Department of Health and Human Services

Tai Chi Cheuk

Javed Khan

Dimiter Stanchev Dimitrov

Zhongyu Zhu

Rimas J Orentas

Sivasubramanian Baskar

James G Taylor, Vi

Monoclonal antibodies selected from immunized mice, immunized rabbits and a human scFv library that specifically bind fibroblast growth factor receptor 4 (FGFR4) are described. Chimeric antigen receptors, antibody-drug conjugates, immunoconjugates, bispecific antibodies and immunoliposomes comprising the disclosed FGFR4-specific antibodies are also described. The antibody compositions can be used to diagnose or treat a FGFR4-positive cancer, such as rhabdomyosarcoma, lung cancer, liver cancer, breast cancer, pancreatic cancer or prostate cancer.

Monoclonal antibodies specific for fibroblast growth factor receptor 4 (FGFR4) and methods of their use

This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly FGFR4 variants, which are linked to increased risk of tumor metastasis. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.

Over-expression and mutation of a tyrosine kinase receptor FGFR4 in tumors

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Germantown, MD, United States of America

Tai Chi Cheuk