Yuhan Corporation

Tai-Au Lee

Tae-Kyun Kim

Dong-Hoon Kim

Hyun-Joo Lee

Young-Ae Yoon

Jae-Young Sim

Myung-Hun Cha

Eun-Jung Jung

Kyoung-Kyu Ahn

Ja-Heouk Khoo

Doo-Byung Lee

Kyoung-Chan Kwon

Jeong-Seok Chae

Sang-Seon Park

Beom-Joo Maeng

Kyu-Jung Wang

Hong-Bae Kim

Chang-Hoe Ku

Nam-Jin Park

Byung-Cheol Lee

The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HTreceptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

Diaminopyrimidine derivatives and processes for the preparation thereof

The present invention provides a process for preparing an imidazole derivative or its salt which comprises reacting a tetrahydrofuran or tetrahydropyran derivative with formamidine or its salt in the presence of a base.

Processes for preparing imidazole derivatives and salts thereof

Provided is a process for preparing terbinafine or its HCl salt comprising: reacting a furan derivative with a base to form a second compound; performing a reductive alkylation of the second compound obtained in the step with N-methyl- -naphthalenemethylamine or its HCl salt to form a third compound; and purifying the third compound.

Process for preparing terbinafine and HCI salt thereof

Provided are a process for preparing &bgr;-D-ribofuranose derivatives, which are useful as an intermediate for the preparation of ribavirin. The process can be performed under a mild condition, in the presence of a catalyst selected from the group consisting of methanesulfonic acid, benzenesulfonic acid and p-toluenesulfonic acid.

Processes for preparing &bgr;-D-ribofuranose derivatives

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Seoul, South Korea

Tai-Au Lee