Innovative Surface Technologies, Inc.

Surmodics, Inc.

Tahmina Naqvi

Patrick E Guire

Jie Wen

Laurie Lawin

Daniel Guire

Briana Vogen

Gary Oppermann

Muhammad Lodhi

Leandro Forciniti

Gary Opperman

The invention provides cell-adherent polymeric coatings for articles, the coating including a synthetic, non-biodegradable polymer having a plurality of pendent amine groups, wherein the polymer is covalently immobilized on the article via latent reactive groups. The invention also provides methods for the long-term attachment of cells using the polymeric coatings.

Polymeric coatings and methods for cell attachment

Inventive concepts relate generally to the field of cell culture, and more particularly to formation of three-dimensional aggregate(s) of eukaryotic cells. Cell culture vessels including a conical device having an inner surface being hydrophobic; and a frustum defining an open viewing aperture and a narrow end of the conical device are described. Ceil culture vessel arrays, assemblies and kits are described, as well as methods of making and using the devices.

Conical devices for three-dimensional aggregate(s) of eukaryotic cells

A stimuli responsive nanofiber that includes a stimuli responsive polymer, such as a thermally responsive polymer, and a cross-linking agent having at least two latent reactive activatable groups. The nanofiber may also include a biologically active material or a functional polymer. The stimuli responsive nanofiber can be used to modify the surface of a substrate. When the nanofiber includes a thermally responsive polymer, the physical properties of the surface can be controlled by controlling the temperature of the system, thus controlling the ability of the surface to bind to a biologically active material of interest.

Methods for preparing thermally responsive cell culture surfaces

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Blaine, MN, United States of America

Tahmina Naqvi