Dong-a Socio Holdings Co., Ltd.

Dong-a St Co., Ltd.

Taesun Park

Taeyoung Yoon

Seong Jin Park

Jin Kwan Kim

Ki Moon Ryu

Sumin Kim

Hadong Kim

Mi Yeon Jang

Myeong-Seop Kim

Joon-Ho Sheen

Myeong-seop Kim

Seung Min Yang

Hae-Sun Kim

Jun Gyu Kim

The present invention provides heterocyclic compounds, the stereoisomer thereof, the enantiomer thereof, or the pharmaceutically acceptable salt, which are capable of modulating the activity of Mer receptor tyrosine kinase (MERTK). This invention also provides pharmaceutical compositions thereof, methods to prepare the said compounds, and the use of such compounds as a medicament. The present invention is directed to MERTK inhibitory compounds with marked potency, thereby having an outstanding potential for a pharmaceutical intervention of cancer and any other diseases related to MERTK dysregulation.

Heteroaryl compounds and their use as therapeutic drugs

The present invention provides a compound of Formula (I) being capable of modulating the activity of histone lysine demethylase (KDM), pharmaceutical compositions thereof, methods to prepare the said compounds, and the use of such compounds as a medicament. The compound of Formula (I) acts as KDM inhibitor with marked potency, thereby having an outstanding potential for a pharmaceutical intervention of cancer and any other diseases related to KDM dysregulation. 

Pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (KDMs)

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Gyeonggi-do, South Korea

Taesun Park