Daiichi Sankyo Company, Limited

Sanford Burnham Prebys Medical Discovery Institute

Taeko Shinozaki

Keisuke Suzuki

Anthony B Pinkerton

Yuko Yamamoto

Shojiro Miyazaki

Masanori Izumi

Masaharu Inui

Kaori Soma

Jun Watanabe

Takayuki Baba

Kenji Murata

Kenji Yoshikawa

Noriyasu Haginoya

Yoshiko Kagoshima

Masashi Numata

Ryutaro Kanada

Mayumi Kitagawa

Akiko Kurimoto

Machiko Shiroishi

Tomoaki Hamada

Eri Tokumaru

The present invention provides a compound or a pharmaceutically acceptable salt thereof having an inhibitory action on the interaction between menin and an MLL protein. The compound represented by the formula (1) or a pharmaceutically acceptable salt thereof. wherein, in the formula (1), the dotted circle, R, R, R, R, R, R, R, R, Ring Q, W, m and n are each as defined in the description.

Cycloalkane-1,3-diamine derivative

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I): wherein Rrepresents a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rand Rare the same or different and each represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rand Rare the same or different and each represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rrepresents a hydrogen atom or the like, each Rmay be the same or different and may each represent an optionally substituted C1-6 alkoxy group or the like, X represents &#x2014;CH&#x2550;, &#x2014;C(&#x2014;R)&#x2550;, or &#x2014;N&#x2550;, and m represents 1 to 4, or a pharmacologically acceptable salt thereof.

Pyridine compounds

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I): wherein Rrepresents a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rand Rare the same or different and each represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, R4 and R5 are the same or different and each represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rrepresents a hydrogen atom or the like, each Rmay be the same or different and may each represent an optionally substituted C1-6 alkoxy group or the like, X represents &#x2014;CH&#x2550;, &#x2014;C(&#x2014;R)&#x2550;, or &#x2014;N&#x2550;, and m represents 1 to 4, or a pharmacologically acceptable salt thereof. 

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Shinagawa-ku, Japan

Taeko Shinozaki