Pangen Biotech Inc.

Taeho Byun

Jaeseung Yoon

Kwanghee Baek

Jongmin Lee

Ji Tai Kim

JeongSoo Park

Hankyu Oh

Jeong Soo Park

The present invention relates to an antibody specifically bound to a coagulation factor VIII or an antigen binding fragment thereof, and a use thereof. More specifically, the present invention relates to: an antibody which is specifically bound to a coagulation factor VIII including specific sequences of heavy chain CDR and light chain CDR, or an antigen binding fragment thereof; a column in which the antibody or the antigen binding fragment thereof is coupled to a column stationary phase as a ligand for isolating or purifying a recombinant coagulation factor VIII; and a method for purifying a recombinant coagulation factor VIII using the same.

Anti-coagulation factor VIII antibody and use thereof

There is provided an expression vector for animal cell having an increased gene expression efficiency, and particularly, an expression vector for animal cells including a MAR element and a SAR element, which are gene expression increasing factors, at a 5' end of a promoter, a 3&#x2032; end of a transcription termination site, or at both of the 5&#x2032; end of the promoter and the 3&#x2032; end of the transcription termination site. The expression vector for animal cells according to the present invention exhibits remarkably increased gene expression efficiency as compared to conventional expression vectors for animal cells, such that protein expression of foreign genes may be significantly increased using this expression vector for animal cells. Particularly, the expression vector for animal cells according to the present invention may be useful in that a high-expression cell line may be secured even without MTX amplification.

Expression vector for animal cells

Growing community of inventors

Gyeonggi-do, South Korea

Taeho Byun