Dana-farber-cancer Institute Inc.

Tae-You Kim

David M Livingston

William G Kaelin

Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. The ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is 'turned on' only under such conditions.

Growing community of inventors

Seoul, South Korea

Tae-You Kim