Sk Biopharmaceuticals Co., Ltd.

Sk Holdings Co., Ltd.

Tae Sung Koo

So Young Lee

Sun Gwan Hwang

Sung Jin Bae

Sang Rak Choi

Jeong Woo Cho

Kyung Chul Cho

Hyeon Cheol Gwon

There is provided a pharmaceutical composition for prevention and treatment of restenosis comprising isoxazole derivatives. The pharmaceutical composition includes a therapeutic effective amount of isoxazole derivatives represented by Formula 1 or pharmaceutically available salts thereof. The pharmaceutical composition may be useful to prevent and treat vascular restenosis since the pharmaceutical composition shows an anti-restenosis activity and accelerates the re-endothelization.

Pharmaceutical composition for prevention and treatment of restenosis comprising isoxazole derivatives

Disclosed herein are isoxazole derivatives and uses thereof. Serving as agonists of Wnt, the isoxazole derivatives activate Wnt/&#x3b2;-catenin signaling and thus can be used in the treatment and prevention of diseases related to the signal transduction. Also, pharmaceutically acceptable salts of the isoxazole derivatives are disclosed.

Isoxazole derivatives and use thereof

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Daejeon, South Korea

Tae Sung Koo