Korea Research Institute of Bioscience and Biotechnology

Korea Institute of Science and Technology

Korea Research Institute of Bioscience

Tae-Sook Jeong

Myung-Sook Choi

Song-Hae Bok

Yang-Kyu Choi

Surk-Sik Moon

Yong-Kook Kwon

Eun-Sook Lee

Ki-Hwan Bae

Yong-Bok Park

Chul-Ho Lee

Byung-Hwa Hyun

Woo-Song Lee

Sae-Bom Lee

Og-Sung Moon

Young-Bae Park

Hyo-Soo Kim

Jong-Min Han

Hyoung-Chin Kim

Kwang-Hee Son

Byoung-Mog Kwon

Young-Kook Kim

Sung-Uk Kim

Jung-Ah Ahn

Doil Choi

Ingyu Hwang

Ho Yong Park

Hyung-Jae Jeong

Ju-Ryoung Kim

So-Jin An

Kyoung-Ran Im

Ki-Chang Jang

Jun-Seock Son

Hyun-Woo Oh

Doo-Sang Park

Byung-Tae Ahn

Yong-Dae Park

Young-Suk Won

Ki Hun Park

Sung-Gyu Kim

Woo Song Lee

Sang-Ku Lee

Ju-Ryong Kim

Han-Ik Cho

Dong-Soon Lee

Jun-Sung Lee

Seong-Choon Choe

The present invention relates to compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts ofleaves or fractions isolated from the same.

Compositions for preventing and treating obesity, hyperlipidemia, atherosclerosis, fatty liver, diabetes or metabolic syndrome containing extracts of glycine max leaves or fractions isolated from the same as an active ingredient

The present invention relates to novel O-acyloxime derivatives, a preparation method thereof and a pharmaceutical composition comprising the same for prevention and treatment of cardiovascular disease. The O-acyloxime derivatives according to the present invention may valuably be used for prevention and treatment of cardiovascular diseases such as hyperlipidemia, coronary arterial heart disease, atherosclerosis, and myocardial infarction caused by Lp-PLA, because they have excellent inhibitory effect of Lp-PLA.

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The present invention relates to a composition for the prevention and treatment of cardiovascular diseases containing the novel quinoline compound, the centipede extracts or compounds isolated from the extracts. The novel quinoline compound, the centipede extracts or a quinoline compound and a phenol compound isolated from the extracts of the invention exhibit excellent LDL-antioxidant activity, ACAT inhibiting activity, and anti-inflammatory activities, so that they can be included as an effective ingredient in a composition for the prevention and treatment of cardiovascular disease including hyperlipidemia, atherosclerosis, coronary heart disease, and myocardial infarction mediated by LDL-oxidation, cholesteryl ester synthesis and accumulation, and inflammation.

Quinoline compound, and composition containing centipede extract or compounds isolated therefrom for prevention and treatment of cardiovascular disease

A method for treating cardiovascular disease, including hyperlipidemia and atherosclerosis, using abietane diterpenoid compound or terpenoid compound isolated fromas an effective ingredient. The abietane diterpenoid compound or terpenoid compound isolated fromnot only excellently inhibits oxidation of low-density lipoprotein (LDL), but also effectively inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity.

Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease

The present invention relates to a method for treating a cardiovascular disease, such as hyperlipidemia or atherosclerosis, with a pharmaceutically effective amount of an extract ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.extracts, abietane diterpenoid compound, or terpenoid compound isolated from the extracts were prepared by extractingleaves, stems, or seeds with water, alcohol, or mixed solution of water and alcohol, which is further fractionized with n-hexane, chloroform and etheyl acetate in that order. Further, the present invention provides a method for inhibiting an oxidation of low-density lipoprotein (LDL) and inhibiting Acyl-CoA:cholesterol acyltransferase (ACAT) using an extract ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient.

The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts ofor abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further,extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.

0A method for treating or preventing an elevated blood lipid level-related disease in a mammal, which comprises administering thereto an effective amount of rutin, quercetin or a mixture thereof.

Method for preventing or treating elevated blood lipid level-related diseases by administering rutin and quercetin

A method for treating or preventing an elevated blood lipid level-related disease in a mammal, which comprises administering thereto an effective amount of rutin, quercetin or a mixture thereof.

The present invention relates to a spice composition comprising 1 to 30 % by weight of garlic, 10 to 50% by weight of onion, 0.2 to 10% by weight of ginger, 5 to 40% by weight of jujube, and 10 to 50% by weight of citrus peel or an extract thereof or 1 to 20% by weight of naringin or hesperidin.

Health-improving spice composition

Flavanone derivatives and composition for preventing or treating blood lipid level-related diseases comprising same

A method for treating or preventing an elevated blood lipid level-related disease such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke and hepatic diseases in a mammal, which comprises administering thereto an effective amount of a cinnamic acid derivative of formula Ia or Ib, or a pharmaceutically acceptable salt thereof:

Method for preventing or treating elevated blood lipid level-related diseases by administering cinnamic acid derivatives

A method for inhibiting a collagen-induced platelet aggregation in a mammal comprises administering an effective amount of a flavonoid derived from citrus peels thereto.

Flavonoids derived from citrus peels as collagen-induced platelet aggregation inhibitor

Methods for inhibiting the activity of acyl CoA-cholesterol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal comprise administering naringin or naringenin thereto.

Naringin and naringenin as inhibitors of acyl

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Daejeon, South Korea

Tae-Sook Jeong