Kanzen Co., Ltd.

Cpikorea Ltd.

Tae.kyu Park

Tae Kyu Park

Won Sup Choi

Da Som Kwon

Hyun Sun Park

The present disclosure relates to novel cell penetrating peptides and their applications in cosmetic compositions. These compositions include cell penetrating botulinum toxin recombinant proteins, which are fusion proteins of the cell-penetrating peptides and botulinum toxin. Also disclosed are polynucleotides encoding these recombinant proteins and recombinant expression vectors comprising these polynucleotides. The cell penetrating botulinum toxin recombinant proteins serve as active ingredients in the cosmetic compositions.

Cell penetrating peptides and uses thereof

Disclosed herein is a recombinant protein including botulinum toxin and cell penetrating peptides and cosmetic composition. The cell penetrating peptide according to the present disclosure may be actively used as a topical agent for various disease treatment, aesthetic, or cosmetic purposes, especially for a cosmetic composition, by securing better convenience as well as maximizing the intrinsic in vivo efficacy of the botulinum toxin through the cell penetrating recombinant proteins that combines the botulinum toxin and a cell penetrating peptide by making skin penetration and/or cell penetration for botulinum toxin more efficient.

Recombinant proteins comprising botulinum toxin and cell penetrating peptide and cosmetic composition comprising thereof

Vehicle headlight including a light emitting unit for emitting a light, an operating member joined with the light emitting unit, the operating member fitted with a magnet, a coil in the vicinity of the operating member for generating a magnetic field, and a housing for holding the operating member and the coil therein, thereby permitting selective lighting of a high beam for regular running at night or a low beam required in crossing an opposite vehicle by using a single light emitting unit and a simple structure.

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Seoul, South Korea

Tae Kyu Park