Dong-a Pharmaceutical Co., Ltd

Dong-a Pharm. Co., Ltd.

Tae Hyun Yoon

Mi-Kyung Kim

Jae Young Lee

Moohi Yoo

Woo Young Kwak

Heung Jae Kim

Jong Pil Min

Soon Hoe Kim

Chang Yell Shin

Moon-Ho Son

Song-Hyen Choi

Sun Ki Chang

Hyun Joo Shim

Yu Na Chae

Kyung Jin Park

Geun Gho Lim

Eun Kyoung Yang

Hadong Kim

Hae-Sun Kim

Gook Jun Ahn

Ji Myun Jang

The present invention relates to an improved method for preparing dipeptidyl peptidase-IV inhibitor intermediates. The present invention is able to reduce preparation costs by using low cost reagents on reaction and is able to be used in mass production by improving yield.

Method for preparing dipeptidyl peptidase-IV inhibitor and intermediate

The present invention relates to an improved method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate. The present invention allows reduction of production costs by reacting low cost reagents, improves yield and is adaptable for mass production.

Method for manufacturing dipeptidyl peptidase-IV inhibitor and intermediate

The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetes or obesity comprising as active ingredients a compound which inhibits the activity of dipeptidyl peptidase-IV (DPP-IV), a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof, and one or more other antidiabetic or antiobesity agents. The pharmaceutical composition exhibits excellent glucose tolerance and may be useful in the prevention and treatment of diabetes, obesity, and the like by effectively inhibiting blood glucose levels and reducing fat mass.

Pharmaceutical composition for prevention and treatment of diabetes or obesity comprising a compound that inhibits activity of dipeptidyl peptidase-IV, and other antidiabetic or antiobesity agents as active ingredients

The present invention provides a novel heterocyclic compound containing a beta-amino group, a method for preparing the same, and a pharmaceutical composition comprising the same heterocyclic compound or a pharmaceutically acceptable salt thereof as an active ingredient. The heterocyclic compound of the present invention exhibits excellent DPP-IV inhibitory activity and bioavailability and therefore can be useful for the prophylaxis or treatment of DPP-IV-related diseases such as diabetes or obesity.

DPP-IV inhibitor including beta-amino group, preparation method thereof and pharmaceutical composition containing the same for preventing and treating diabetes or obesity

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Seoul, South Korea

Tae Hyun Yoon