Postech Academy-industry Foundation

Posco

Pohang University of Science and Technology Foundation

Postech Foundation

Tae-Hoon Lee

Sung-Ho Ryu

Pann-Ghill Suh

Do-Hyung Kim

Il-Shin Kim

Mi-Nam Lee

Hyun-Ju Lee

Sang-Hoon Ha

Yoe-Sik Bae

Youn-Dong Kim

Sung-Key Jang

Hyunjoo Bae

Jung-Hwan Kim

Jong Heon Kim

Seung-Je Lee

Byoung-Dae Lee

Jae-Yoon Kim

Jong-Hyun Kim

Kyung-Moo Yea

The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.

Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and raptor

The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.

Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb

Disclosed are peptides having SEQ ID NOs: 1 to 32 that can stimulate superoxide generation in human monocytes. Superoxide is the most important armory on the primary defense line of monocytes against invading pathogens, and the identification of new stimuli and the characterization of the regulatory mechanism of superoxide generation are of paramount importance.

Immune-enhancing peptides

Growing community of inventors

Pohang, South Korea

Tae-Hoon Lee