Ckd Bio Corp.

Tae-Hee Han

Heui-Il Kang

Yun-Beom Ham

Heung-Mo Kang

Doo-Jin Kang

Su-Hyun Kyong

The present invention relates to a novel process for preparing the aza cyclohexapeptide compound 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B(caspofungin) represented by the following formula 1, which can improve the problem due to a pungent odor and toxicity during the process and can prepare caspofungin as a final product at high yield compared to conventional processes, and to novel intermediates which are used in the preparation process: 

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Hwaseong-si, South Korea

Tae-Hee Han