Fotona D.o.o.

Tadej Perhavec

Matjaz Lukac

Marko Kazic

Marko Marincek

Zdenko Vizintin

Nejc Lukac

Franci Bajd

Blaz Tasic Muc

Matjaz Lukač

Nejc Lukač

Anže Zorman

Marko Leskovar

Janez Zabkar

The present disclosure relates to a method and an apparatus for generating a laser pulse sequence for application to a predetermined target tissue. Means are provided for setting a cumulative fluence Fof the laser pulse sequence. Means are provided for determining a duration of the laser pulse sequence as a function of the cumulative fluence Fsuch that the predetermined target tissue is heated to a final temperature that is within a predetermined range.

Non-ablative resurfacing of soft tissues

A treatment method for non-ablative tissue regeneration includes directing at least one laser pulse having a wavelength onto a tissue surface of a human or animal body, and controlling an energy delivery time tof the at least one laser pulse, during which the second half of the pulse energy is delivered, to be sufficiently short, so that, given the wavelength and thus a corresponding penetration depth δ of the at least one laser pulse, a thermal exposure time tof the tissue surface is smaller than 900 microseconds. The thermal exposure time tof the tissue surface is defined as a time interval in which the temperature of the tissue surface is above T+(T−T)/, wherein Tdefines the initial temperature of the tissue surface, before the laser pulse arrives, and Tis a maximal temperature of the tissue surface.

Apparatus and method for tissue regeneration

A treatment method for non-ablative tissue regeneration includes directing at least one laser pulse having a wavelength onto a tissue surface of a human or animal body, and controlling an energy delivery time tof the at least one laser pulse, during which the second half of the pulse energy is delivered, to be sufficiently short, so that, given the wavelength and thus a corresponding penetration depth &#x3b4; of the at least one laser pulse, a thermal exposure time tof the tissue surface is smaller than 900 microseconds. The thermal exposure time tof the tissue surface is defined as a time interval in which the temperature of the tissue surface is above T+(T&#x2212;T)/2, wherein Tdefines the initial temperature of the tissue surface, before the laser pulse arrives, and Tis a maximal temperature of the tissue surface.

An apparatus for tissue regeneration is provided. The apparatus comprises means for generating at least one laser pulse comprising a wavelength; and means for directing the at least one laser pulse onto a tissue surface of a human or animal body, wherein the means for generating comprises control means to ensure that a sum of the pulse energies of the at least one laser pulse is selected so that the corresponding fluence on the tissue surface heats the tissue surface up to a maximal temperature Tbetween 70&#xb0; C. and a tissue boiling temperature T. Further, the means for generating of the apparatus are adapted so that a delivery time tof the at least one laser pulse (during which the second half of the pulse energy is delivered) is sufficiently short so that, given the wavelength and thus a corresponding penetration depth &#x3b4; of the at least one laser pulse, a thermal exposure time tof the tissue surface is shorter than 900 microseconds. Here, the thermal exposure time tof the tissue surface is defined as a time interval in which the temperature of the tissue surface is above T+(T&#x2212;T)/2, wherein Tdefines the initial temperature of the tissue surface, before the laser pulse arrives.

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Ljubljana, Slovenia

Tadej Perhavec