Takeda Pharmaceutical Company Limited

Takeda Chemical Industries, Inc.

Toray Industries, Inc.

Tadatoshi Hashimoto

Shigenori Ohkawa

Tetsuya Tsukamoto

Shuji Hinuma

Junya Shirai

Ryo Fujii

Naoki Izumimoto

Makoto Kobayashi

Kuniaki Kawamura

Naoki Tarui

Yoshinori Ikeura

Hiroshi Nagabukuro

Yasuaki Ito

Toshikazu Komagata

Kohji Fukatsu

Yasuhiro Tanaka

An analgesic which may be applied to wide variety of pain from various causes is disclosed. The analgesic comprises as an effective ingredient a specific morphinan derivative having a nitrogen containing heterocyclic group, such as compound 1: 

Analgesic and methods of treating pain

By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.

Screening method for binding property or signal transduction alterations

The present invention provides a compound represented by the formula:  wherein Ar is an aryl group, an aralkyl group or an aromatic heterocyclic group, each of which may be substituted, Ris a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group, X is an oxygen atom or an optionally substituted imino group, Z is an optionally substituted methylene group, Ring A is an optionally further substituted piperidine ring, and Ring B is an optionally substituted aromatic ring, provided that when Z is a methylene group substituted with an oxo group, Ris not a methyl group, and when Z is a methylene group substituted with a methyl group, Ring B is a substituted aromatic ring, or a salt thereof, which is a novel piperidine derivative having excellent antagonistic action for a tachykinin receptor and useful as a medicament, particularly an agent for preventing and/or treating urinary frequency and/or urinary incontinence.

Piperidine derivative, process for producing the same, and use

A compound represented by the formula (I):

Dihydrobenzofuran derivatives, process for the preparing thereof and agents

A compound represented by the formula:wherein Ring A is a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, Ring B is benzene ring which is further substituted, Ring C is a dihydrofuran-ring which may be further substituted and R is hydrogen atom or an acyl group or a salt thereof has an excellent lipid peroxidation inhibitory activity and is useful as a lipid peroxidation inhibitor.

Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof and agents

Cyclic ether compounds as sodium channel modulators

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Ibaraki, Japan

Tadatoshi Hashimoto