Merck + Co., Inc.

Other

Meiji Seika Kaisha, Ltd.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Tadashi Wakazawa

Seiji Shibahara

Shunzo Fukatsu

Taro Niida

Yasushi Murai

Tsuneo Okonogi

Burton G Christensen

Hamao Umezawa

Sumio Umezawa

Toshio Yoneta

Shunzo Futkatsu

Tsuneo Okonogy

The subject invention includes a 1-oxa-1-dethia-cephalosporin compound represented by the general formula (1) ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## where R.sup.5 is a methyl group, an ethyl group, a carboxymethyl group or a 2-carboxy isopropyl group, or R.sup.1 is a group of the formula: ##STR3## where R.sup.6 is a hydrogen atom, a 4-ethyl-2,3-dioxopiperazine-1-yl group, a 3,4-dihydroxy phenyl group or a 5- and 6-membered heterocyclic radical having 2 ring nitrogens as the sole hetero substituent in the ring and having at least one hetero group on the carbon adjacent to the ring nitrogens.

1-oxa-1-dethia-cephalosporin compounds and antibacterial agent

Disclosed is a process for preparing antibiotic 1-oxadethiacephalosporins via diazo-species I: ##STR1## wherein: A is acyl; R.sup.1 is H or OCH.sub.3 ; and R.sup.2 is a protecting group.

Process for the production of antibiotic 1-oxadethiacephalosporins, and

This invention relates to 1-oxa-1-dethia-cephalosporins which are useful as anti-biotics.

1-Oxa-1-dethia-cephalosporin derivatives

New 1-Oxadethiacephalosporins having a 3-loweralkyl thio group, and antibacterial compositions containing the same.

1-Oxadethiacephalosporin compound and antibacterial agent containing the

Processes for the production of antibiotic 1-oxadethiacephalosporins

There are provided new compounds, 3',4'-anhydro-4'-epi derivatives of kanamycin A of the formula: ##STR1## wherein R represents an alkyl, aralkyl or aryl group and Y represents an alkylidene, aralkylidene, cycloalkylidene or tetrahydropyranylidene group which are useful as an intermediate for the synthesis of 3',4'-dideoxykanamycin A and 4'-deoxykanamycin A from kanamycin A. The compounds of formula (I) can be prepared by treating the corresponding 4'-O-sulfonyl derivative with an alkali metal alcoholate in a lower alkanol under an alkaline condition.

Derivative of kanamycin A and a process for the preparation thereof

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Yokohama, Japan

Tadashi Wakazawa