Ajinomoto Co., Ltd.

Central Research Laboratories Ajinomoto Co., Inc.

Tadashi Takemoto

Yusuke Amino

Toyoto Hijiya

Kenichi Mori

Shigeru Kawahara

Ryoichiro Nakamura

Nao Funakoshi

Kazutaka Nagashima

Kazuko Yuzawa

Toshihide Yukawa

Masakazu Sugiyama

Shinji Fujita

Kunihiko Watanabe

Kunio Hisamitsu

Shinichi Kishimoto

Satoji Takahashi

Eriko Ono

Toshihisa Kato

Chiaki Mochizuki

Teruo Yonekawa

Ken-ichi Mori

Yasuo Ariyoshi

Yuuichi Aoki

Naoko Sugiyama

Takeshi Nagai

Toru Ikeda

Yuichi Suzuki

Hideo Takeda

Chikahiko Eguchi

Akihiro Kishishita

Takehiko Kataoka

Yoichi Ozawa

Hirotoshi Ishida

Fusayoshi Kakizaki

Emiko Shinohara

Mikiya Kano

Katsumi Sugiyama

Nobuyoshi Kitamura

Kazuko Hirasawa

Sou Abe

Satoshi Kumon

Harutoshi Ohura

Ichiro Noda

Tetsuo Yamatani

Masahiko Oshimura

Makoto Nishikawa

Hajime Kamada

Yusuki Amino

A process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin is described. This process entails converting a substituted &#x3b1;-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same. 

Process of producing glutamate derivatives

The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted &#x3b1;-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same. 

Process for producing glutamate derivatives

The present invention is to provide an industrially advantageous method for producing an amino acid derivative. Provided is a method for producing an amino acid derivative including contacting a microorganism and/or an enzyme with a hydroxyimino acid represented by the following general formula (I):  

Process for producing amino acid derivative from hydroxyimino acid

The present invention provides salt crystals of non-natural stereoisomer forms of monatin and to the use thereof.

Crystals of non-natural-type stereoisomer salt of monatin and use thereof

A crystal of free (2R,4R)-monatin is useful as a sweet substance. The crystals resist absorption of water even under high humidity, are stable and exhibit a high degree of sweetness. Thus, such crystals may used as a sweetening agent or an ingredient thereof, and as an ingredient for imparting sweetness to foods and beverages.

Crystals of free (2R, 4R)-monatin and use thereof

Crystals of (2R,4R)-monatin potassium salt which exhibit an X-ray powder diffraction pattern having characteristic peaks at diffraction angles 2&#x3b8; of 5.5&#xb0;, 7.2&#xb0;, 8.1&#xb0;, 8.9&#xb0;, and 16.3&#xb0;, by powder X-ray diffraction (Cu&#x2014;K&#x3b1; radiation), are superior in sweetness, preservation stability, solubility, and color stability.

Crystal of (2R,4R)-monatin potassium salt and sweetener composition containing same

A solution to be treated containing monatin and impurities is treated with a nonpolar resin having aromatic rings, whereby monatin is separated from the solution. Treatment with the nonpolar resin having aromatic rings results in efficient separation of monatin under a mild pH condition.

Method for producing monatin

By simultaneously carrying out an isomerization reaction at position 2 of monatin in different configurations at positions 2 and 4 in the presence of an aldehyde under a condition of pH 4 to 11 in a mixture solvent of water and an organic solvent, and the crystallization of monatin in the same configurations at positions 2 and 4 or a salt thereof, monatin useful as a sweetener, particularly optically active monatin can efficiently be produced.

The present invention relates to processes of producing glutamic acid compounds, for example, monatin, which are useful as, for example, production intermediates for sweetener or pharmaceutical products.

Processes of producing glutamic acid compounds and production intermediates therefore and novel intermediate for the processes

The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted &#x3b1;-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same 

The present invention provides N-alkylaspartyl dipeptideester compounds and salts thereof, such as N-[N-[3-(3-hydroxy-4-methoxyphenyl)-3-methylbutyl]-L-&#x3b1;-aspartyl]-L-phenylalanine 1-methyl ester, which provide high degrees of sweetness in comparison to conventional products, compositions and products containing the novel aspartyl dipeptide ester compounds and method of producing the novel aspartyl dipeptide ester compounds.

N-alkylaspartyl dipeptide ester compounds

A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in the presence of an alkali, in particular preferably, dropping acetaldehyde little by little thereto in an aqueous solution at a low temperature for the reaction thereof. The cinnamaldehyde derivative thus obtained is selectively reduced to produce 3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propionaldehyde. Further, through a reductive alkylation reaction of the compound thus produced with an aspartame, N-[N-[3-(3-hydroxy-4-substituted (with methoxy group or the like)phenyl)propyl]-L-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high sweetening potency, can be industrially and efficiently produced. The processes therefor are also provided.

Process for producing cinnamaldehyde derivatives, use thereof and the like

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Kawasaki, Japan

Tadashi Takemoto