Nippon Soda Co., Ltd.

Tadashi Sugiura

Shiro Tsubokura

Hidekazu Miyazaki

Kaoru Noda

Satoru Yanaka

Kengo Suzuki

Tsutomu Inoue

Yuuki Nakagawa

Akira Mitani

Isamu Kasahara

Yoshikazu Ito

Hiroshi Sano

Takahiro Ando

Tatsumi Suzuki

Hiroshi Hamamura

Disclosed is a compound containing a pyridine ring that can be synthesized in an industrially advantageous manner, and is useful as an intermediate for producing tetrazolyloxime derivatives that exhibit fungicidal activity (wherein Rrepresents a Calkoxy group, Calkoxy-Calkoxy group or the like, Rrepresents a Calkoxycarbonyl group, acetyl group or the like, Z represents a halogen atom, cyano group or the like, X represents a halogen atom, and n represents an integer of 0 to 3), and industrially advantageous production methods for producing 2-substituted amino-6-halomethylpyridine derivatives and tetrazolyloxime derivatives.

Compound containing pyridine ring and method for producing halogenated picoline derivative and tetrazolyloxime derivative

Disclosed is a compound containing a pyridine ring that can be synthesized in an industrially advantageous manner, and is useful as an intermediate for producing tetrazolyloxime derivatives that exhibit fungicidal activity (wherein Rrepresents a Calkoxy group, Calkoxy-Calkoxy group or the like, Rrepresents a Calkoxycarbonyl group, acetyl group or the like, Z represents a halogen atom, cyano group or the like, X represents a halogen atom, and n represents an integer of 0 to 3), and industrially advantageous production methods for producing 2-substituted amino-6-halomethylpyridine derivatives and tetrazolyloxime derivatives. 

The present invention provides a process for preparation of 1-alkyl-5-benzoyl-1H-tetrazole derivative including a step 1 of reacting a ketoamide derivative represented by formula (I) (in formula (I), A represents a halogen atom or the like; n represents an integer of 0 to 5; Y represents an alkyl group) with a halogenating agent to obtain an imidoyl halide derivative represented by formula (II) (in formula (II), A, n and Y are as defined above; X represents a halogen atom); and a step 2 of reacting the imidoyl halide derivative represented by formula (II) with an azide represented by formula (III) (in formula (III), M represents an alkali metal or the like; m represents 1 or 2) to obtain a 1-alkyl-5-benzoyl-1H-tetrazole derivative represented by formula (IV) (in formula (IV), A, n and Y are as defined above). 

Process for preparation of 1-alkyl-5-benzoyl-1H-tetrazole derivatives

Oxime O-ether compounds and fungicides for agricultural and horticultural use

The present invention is to provide 2,3-dihalogeno-6-trifluoromethylbenzene derivatives represented by a general formula [I]; ##STR1## wherein X.sub.1 and X.sub.2 are the same or different and each independently represents fluoro or chloro; Y represents COOH, CONH.sub.2, CN, CHO, CH.dbd.NOH or COOR', wherein R' is C.sub.1 -C.sub.4 alkyl, except the case that X.sub.1 and X.sub.2 are each chloro and Y is COOH, which are useful as the starting materials for producing pesticides, drugs and the like, and a process for producing such derivatives.

2, 3-dihalogeno-6-trifluoromethylbenzene derivatives and process for

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Odawara, Japan

Tadashi Sugiura