Ss Pharmaceutical Co., Ltd.

Tadashi Narita

Hiroshi Hasegawa

Takeshi Kotsugai

Takemitsu Asaoka

Tatsuhiko Katori

Hiromichi Eto

Kazuhiro Imai

Tetsuo Tomiyama

Koichi Yokoi

Noriaki Shioiri

Toshiaki Nakashima

Kenichi Kukita

Seiji Ishizeki

Shigeo Narita

Disclosed are SH-labeling reagents containing acridine compounds represented by the following formula (I):

Reagents for labeling SH groups, process for the preparation of them and method for labeling with them

Method for detecting blood component using conidiobolus hemagglutinin

Novel .gamma.-butyrolactone derivatives having strong ACE inhibitory activity are provided. They are represented by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and mean individually a hydrogen atom or a straight-chain or branched alkyl or cycloalkyl group, or R.sup.1 and R.sup.2 are bonded together to mean an alkylene group having 2-6 carbon atoms, R.sup.3 denotes a hydrogen atom or a lower alkyl, aralkyl, amino lower alkyl or lower alkoxycarbonylamino lower alkyl group, R.sup.4 means a lower alkyl, cycloalkyl or aralkyl group, R.sup.5 means a hydrogen atom or a lower alkyl group, or R.sub.4 and R.sub.5 are bonded together to denote an alkylene group having 2-4 carbon atoms, and R.sup.6 stands for a hydrogen atom or a lower alkyl or aralkyl group; or a pharmacologically acceptable salt thereof.

Novel gamma-butyrolactone derivatives

Disclosed herein are Fredericamycin A derivatives, each, represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or acyl group, A denotes ##STR2## and dotted bonds are optional, with a proviso that when A is ##STR3## or the dotted bonds are contained, R is other than hydrogen atom. They have excellent antibacterial and antitumor activities and at the same time, are extremely stable compared with Fredericamycin A.

Novel Fredericamycin A derivatives

Growing community of inventors

Shisui-machi, Japan

Tadashi Narita