The Institute of Physical and Chemical Research

Other

The Institute of Physical and Chemical Research, and Kunio Suzuki

Tadashi Nakata

Takeshi Shimizu

Kunio Suzuki

Kotaro Enomoto

Kimito Funatsu

Hiroko Satoh

Keiko Takano

A molecule surrounding surface () is set so as to be reflected in the spatial dimension of a molecule. A molecule surrounding space surrounded by the molecule surrounding surface is divided into a plurality of component spaces (), by which the reaction characteristic of the molecule is characterized. Probe points are provided on a frontier surrounding surface () on the molecule surrounding surface, and a space occupied rate is derived for each of the component spaces. Electrostatic energies are derived for each of the probe points on the frontier surrounding surface, and the sum of the electrostatic energies on the frontier surrounding surface is derived as a enelectrostatic factor of each of the component spaces. In addition, van der Waals energies are derived for each of the probe points, and the sum of the van der Waals energies on the frontier surrounding surface is derived as a steric factor of each of the component spaces. Assuming that the space occupied rate, the electrostatic factor and the steric factor are reaction characteristic values of the corresponding one of the component spaces, the reaction characteristic of the molecule is predicted on the basis of the reaction characteristic values of each of the component spaces.

Method for predicting reaction characteristics of molecules

A medicament for preventive and therapeutic treatment of obesity and a disease with abnormal lipid metabolism which comprises a 24-alkylcholest-5-en-3-one as an active ingredient.

Medicament for treating obesity and improving lipid metabolism

A medicament for preventive and therapeutic treatment of obesity and a disease with abnormal lipid metabolism which comprises as an active ingredient a compound selected from the group consisting of 24-alkylcholestan-3-ones and 24-alkylcholesten-3-ones such as 24-alkylcholestan-3-ones, 24-alkylcholestmonoen-3-ones, 24-alkylcholestdien-3-ones, 24-alkylcholesttrien-3-ones and 24-alkylcholesttetraen-3-ones.

Anti-obesity agents which comprise 3-ketosteroid compounds as an active ingredient are provided. The anti-obesity agents of the present invention have a high anti-obesity effect with little or no side effects and toxicity. Food products which contain anti-obesity agents comprising 3-ketosteroid compounds as an active ingredient, pharmaceutical compositions which comprise 3-ketosteroid compounds as an active ingredient and pharmaceutically acceptable carriers, and methods for preventing and treating obesity which comprise administering an effective amount of a 3-ketosteroid compound to a human are also provided.

Growing community of inventors

Saitama, Japan

Tadashi Nakata