Tobishi Pharmaceutical Co., Ltd.

Senga Pharmaceutical Laboratory Inc.

Tadashi Morita

Norihiro Iibuchi

Masashi Ogawa

Shinpei Kidokoro

Hideyuki Tsutsui

Kiyoshi Matsuda

A thiazolidinedione derivative represented by the following general formula (I): ##STR1## �wherein the dotted line represents a single bond or a double bond, the thiazolidinedione ring residue is linked to either of 2-, 3-, 4-, 5- and 6-positions on the indole ring and R represents a group selected from the group consisting of hydrogen atom and alkyl, alkenyl, alkynyl, phenyl, aralkyl, heterocycloalkyl, arylsulfonyl and arylaminocarbonyl groups! or a pharmaceutically acceptable salt thereof exhibits excellent effects of reducing the blood sugar level and of reducing the lipid concentration in blood and is accordingly useful as a therapeutic agent for treating diabates mellitus. These derivatives and pharmaceutically acceptable salt thereof are almost free of any side effect.

Thiazolidinedione derivatives, method for preparing the derivatives and

A compound represented by the formula (1): ##STR1## wherein, m is an integer of 1 to 3;

Amino acid derivative having anti-CCK activity

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Hamura, Japan

Tadashi Morita