Sumitomo Chemical Company, Limited

Tadashi Mizuno

Tadashi Katsura

Nobuhiro Arai

Hideo Muraoka

Masayoshi Minai

Nobushige Itaya

Toshiya Takahashi

Isao Kurimoto

Masahiko Mizuno

Norihiko Hirata

Yasunobu Miyamoto

Yasuo Matsumoto

Yoshinori Kobayashi

Takahiro Yamamoto

Taro Ishibahsi

Erina Honda

Masamitu Fukuda

A method for producing N-methacryloyl-4-cyano-3-trifluoromethylaniline, wherein 4-cyano-3-trifluoromethylaniline is crystallized from a mixed solvent of methanol and water, and the obtained 4-cyano-3-trifluoromethylaniline is reacted with methacryloyl chloride improved separation property even in industrial production in a large scale.

Method for producing N-methacryloyl-4-cyano-3-trifluoromethylaniline

The present invention provides a method of crystallization of bicalutamide comprising adding an acetone solution containing bicalutamide to water; crystals of bicalutamide wherein particle size distribution of the crystals is 1 to 10 &#x3bc;m of Dp, 10 to 25 &#x3bc;m of Dpand 25 to 100 &#x3bc;m of Dp, and the crystals are obtainable by the method described above; and crystals of bicalutamide, wherein particle size distribution of the crystals is 1 to 3 &#x3bc;m of Dp, 2 to 5 &#x3bc;m of Dpand 5 to 15 &#x3bc;m of Dp.

Method of crystallization of bicalutamide

This invention provides a process for producing an epoxytriazole derivative represented by formula (2): (wherein R and Ar are defined below),which comprises a step including a reaction of an epoxy derivative represented by formula (1'): (wherein R represents a hydrogen atom or C1-12 alkyl group and Ar represents an aromatic group optionally substituted by a halogen atom(s) or trifluoromethyl group(s), and X&#x2032; represents a hydroxy group or leaving group),with 1,2,4-triazole in the presence of a base and water.

Process for producing epoxytriazole derivative

An epoxy compound of the formula (1): wherein, R represents a hydrogen atom or an alkyl group having 1 to 12 carbon atoms, and Ar represents an optionally substituted aromatic group, can be purified by dissolving a crude product containing the epoxy compound (1), an aprotic polar solvent and an alkali metal salt in a two-phase solvent composed of water and an organic solvent, which is capable of phase-separating from water, obtaining the organic layer by phase separation, washing with water and then subjecting to isolation of the epoxy compound (1) without decomposition.

Method of purifying epoxy compound

The present invention provides a process for recovering 1,3-dimethyl-2-imidazolidinone comprising extracting 1,3-dimethyl-2-imidazolidinone from an aqueous solution containing it with n-butanol in the presence of an inorganic salt to obtain n-butanol layer and, subjecting the n-butanol layer to distillation. As 1,3-dimethyl-2-imidazolidinone can be recoverable at high purity from an aqueous solution containing 1,3-dimethyl-2-imidazolidinone easily and efficiently without using alkali, the present process is industrially advantageous.

Process for recovering 1,3-dimethyl-2-imidazolidinone

A process for producing a thiophene derivative represented by a general formula (2) involves catalytically reducing a compound represnted by the general formula (1) with hydrogen in a solvent mixture of at least one of alcohol and water in the presence of a palladium catalyst soluble in organic solvents. A thiophene derivative is useful in preparing biotin (Vitamin H).

Process for producing thiophene derivatives

A process for producing acrolein which comprises bringing a reaction gas resulting from a catalytic oxidation of propylene into contact in a cooling tower with a condensate which is being circulated through the cooling tower and a circulating part, thereby to cool and separate the reaction gas and discharge an effluent gas from the cooling tower, the condensate in a bottom part of the cooling tower having a temperature of from 35.degree. to 50.degree. C., the effluent gas discharged from the cooling tower having a temperature of from 35.degree. to 55.degree. C., the temperature of the effluent gas being kept nearly equal to or higher than the temperature of the condensate in the bottom part of the cooling tower, and a process for producing acrolein which comprises bringing a reaction gas resulting from the catalytic oxidation of propylene into contact in a cooling tower with a condensate which is being circulated through the cooling tower and a circulating part, thereby to cool and separate the reaction gases, the period of the residence time of the condensate in the cooling tower and the circulating part being from 0.5 to 3 hours.

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Ibaraki, Japan

Tadashi Mizuno