Fujisawa Pharmaceutical Company, Ltd.

Tadashi Kitaguchi

Ikuo Ueda

Masakazu Kobayashi

Takao Takaya

Hisashi Takasugi

Takashi Masugi

Hiromu Kochi

Mineo Niwa

Hiroki Ono

Yoshimasa Saito

Susumu Sato

Susumu Satoh

Yoshimasa Saitoh

Chihiro Kusunoki

IGF-I fused with a protective peptide, in which the protective peptide is a protein peptide and is used for the protection of IGF-I from degradation by protease in cells of E. coli is disclosed. Also disclosed are genes coding for the fused IGF-I's, plasmids containing the genes, and E. coli microorganisms transformed with the plasmids.

IGF-I fusion proteins; protection of IGF-I from degradation by host

IGF-I fusion proteins; protection of IGF-I from degradation by host cell

The present invention relates to a .sup.59 Valine insulin-like growth factor I (.sup.59 Val.IGF-I), to a .sup.59 Val-IGF-I fused to a protective peptide, to a gene coding for .sup.59 Val-IGF-I, to a gene coding for fused .sup.59 Val-IGF-I, to a plasmid containing the .sup.59 Val-IGF-I gene, to a host organism containing a plasmid containing the .sup.59 Val-IGF-I gene, to a host organism containing a plasmid containing the fused .sup.59 Val-IGF-I gene, and to processes for the production of these.

.sup.59 Valine insulin-like growth factor I and process for production

The invention relates to novel cephem compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,

Cephem compounds

This invention concerns antibiotic cephalosporins of the formula ##STR1## wherein R.sup.1 is amino or protected amino; R.sup.2 is halogen; R.sup.3 is alkyl; and R.sup.6 is carboxy or protected carboxy.

Cephem compounds and processes for preparation thereof

The invention relates to new antimicrobially active 3-cephem compounds, processes for preparing such compounds, new intermediate compounds comprising alkoxyimino dioxy butyric acid derivatives useful in said processes, and processes for preparation of said intermediates.

2-alkoxyimino-3,3-dialkoxy-butyrates and derivatives

The invention relates to new compounds comprising alkoxyimino dioxy butyric acid cephem derivatives of high antimicrobial activity.

3-Cephem intermediates

This invention relates to new compounds comprising alkoxyimino dioxy butyric acid cepham derivatives, useful as intermediates in the production of antimicrobial agents.

Growing community of inventors

Kukuchinishimachi, Japan

Tadashi Kitaguchi