Santen Pharmaceutical Co., Ltd.

Tadashi Iso

Masayuki Oya

Jun-ichi Iwao

Takakazu Morita

Takehisa Chiba

Junichi Iwao

Toshio Baba

Shiro Mita

Youichi Kawashima

Hideyasu Yamauchi

Yoichi Kawashima

Tadashi Fujita

Hideo Takashina

Hiroshi Masuda

Mitsushi Hikida

Itaru Mita

Eishin Kato

Takihisa Chiba

This invention relates to cysteine derivatives of the formula[I] and salts thereof. ##STR1## The compounds of this invention are useful for immunomodulator and treatment of liver disorder.

Cysteine derivatives

A compound of the formula [II] or pharmaceutically acceptable salt thereof, ##STR1## wherein R.sup.1 is hydrogen or fluorine;

Agent for treatment of disorders of the cerebro-neural transmission

This invention relates to cyclic sulfur-containing compounds of the formula [I] and salts thereof which are useful for immunomodulator and treatment of liver diseases. ##STR1##

Cyclic sulfur-containing compounds

A method for treatment of disorders of the cerebro-neural transmission system which comprises administering a compound of the formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically effective amount, either alone or in admixture with one or more pharmaceutically acceptable excipients, ##STR1## wherein Ar or Ar' is unsubstituted or substituted phenyl or pyridyl; R is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy; A is C.sub.1 -C.sub.6 alkylene; and n is 0 or 1. A compound of the formula (II) or a pharmaceutically acceptable salt thereof, ##STR2## wherein R.sup.1 is hydrogen or fluorine; R.sup.2 is hydrogen or fluorine; R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy; A is lower C.sub.1 -C.sub.6 alkylene, and n is 0 or 1, provided that at least one of R.sup.1 or R.sup.2 is fluorine.

A pharmaceutical composition for treatment of an autoimmune disease, which comprises (i) a pharmaceutical carrier and (ii) a compound of the formula (I) or pharmaceutically acceptable salts thereof in an amount effective for treatment of an autoimmune disease, ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is lower alkyl; and R.sup.3 is hydrogen or lower alkyl.

Compositions and methods of use of cyclic sulfur-containing compounds

Cyclic sulfur-containing compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is hydrogen or lower alkyl,

Anti-allergic ophthalmics

Novel benzothiazine derivatives

This invention relates to benzothiazine derivatives represented by the formula [I] and salts thereof, which are useful for treatment of cardiovascular diseases. ##STR1##

Platelet anti-aggregative- and calcium antagonistic

The invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;

Benzothiazoline compounds which contain a carbonyl group useful for

3-Alkanoyl benzothiazoline compounds useful for treating cardiovascular

Aletheine derivatives of the general formula ##STR1## which are useful for treatment of liver damage.

Aletheine derivatives

This invention relates to novel benzothiazoline derivatives of the formula [I] and salts thereof, ##STR1## wherein R.sup.1 is formyl or lower alkanoyl;

2-Arylbenzothiazoline derivatives and their use in treating angina cordis

Cysteine derivatives of disulfide form

Thiazolidine and pyrrolidine compounds which have the general formula ##STR1## and salts thereof for preventing or relieving diabetic complications and for reducing blood pressure, the processes for their preparation, and the compositions comprising them and pharmaceutically acceptable excipient(s).

Growing community of inventors

Sakai, Japan

Tadashi Iso