Olympus Corporation

Chiba University

Nihon Medi-physics Company, Limited

Kagoshima University

Tadashi Hatano

Toshihiko Hashiguchi

Yuji Ito

Hiroyuki Suzuki

Yasushi Arano

Yoshinari Shoyama

Yu Ogawa

Tomoya Uehara

Shota Komoto

Described is a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH (SEQ ID NO: 2) wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.

Modified antibody and radioactive metal-labelled antibody

A rigid endoscope for prostate biopsy includes: an insertion portion including a distal end portion including an ultrasound transmission and reception portion, and a bent portion bent at a predetermined curvature; a treatment instrument insertion channel that passes through inside the bent portion and includes a first opening portion provided on a distal end side and a second opening portion provided on a proximal end side; a shaft-shaped portion installed to extend in a proximal end direction of the bent portion along a straight line passing through an inflection portion provided between the distal end portion and the bent portion; and a grasping portion that includes the shaft-shaped portion.

Rigid endoscope for prostate biopsy and treatment instrument

Growing community of inventors

Tokyo, Japan

Tadashi Hatano