Mitsui Chemicals, Inc.

Tadashi Araki

Tomonori Hidesaki

Kiyoteru Nagahara

Hitoshi Takahashi

Takashi Morishige

Daisuke Mochizuki

Mitsufumi Wada

Seiichi Watanabe

Mitsuo Koito

Keita Nishida

Toshihiro Oikawa

Katsuyuki Takahashi

Reiko Abe

Ichirou Ikeda

Junko Tokuda

Hiroki Ishibashi

Kaori Matoishi

Yasushi Fukuiri

Yasuko Matsuba

Hitoki Miyake

Daisuke Miyazawa

Hiroshi Shimizu

Masayuki Furuya

Nobuyuki Fukazawa

Hidetoshi Hayashi

Tomoyuki Ando

Hideki Sawai

Takashi Mimitsuka

Takeshi Nakamura

Katsutoshi Tsuchiya

Hironori Komatsu

Kiyoshi Ito

Tamotsu Asano

Nozomi Takebayashi

Hideki Umetani

Yosuke Higashi

Yoshiko Matsumoto

Ryota Fujii

Chikara Furusawa

Anjali Madhavan

Su Sun Chong

Tomokazu Shirai

Koh Amano

Takashi Hirasawa

Junya Fujiwara

Toshihiro Tateno

Miyuki Kawashima

Akiko Natsuji

Mitsufumi Wade

Hirokazu Awano

Tomoyuki Natsuji

Tomomi Sakai

Kyoko Maruyama

Takahiro Yamauchi

Dominik Lukas Jürgen-Lohmann

Ayako Endo

This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.

DNA encoding novel enzyme having D-serine synthase activity, method of producing the enzyme and method of producing D-serine by using the same

An acetyl-CoA-producing microorganism, which is capable of efficiently synthesizing acetyl-CoA using carbon dioxide, and a substance production method using the same are provided. An acetyl-CoA-producing microorganism including an acetyl-CoA production cycle obtained by imparting at least one type of enzymatic activity selected from the group consisting of malate thiokinase, malyl-CoA lyase, glyoxylate carboligase, 2-hydroxy-3-oxopropionate reductase, and hydroxypyruvate reductase, to a microorganism.

Microorganism having carbon dioxide fixation pathway introduced thereinto

A mutant lysine decarboxylase produced by replacing at least one of the amino acids in SEQ ID NO:4 with another amino acid.

Method for producing 1,5-pentamethylenediamine, mutant lysine decarboxylase, method for producing 1,5-pentamethylene diisocyanate and method for producing polyisocyanate composition

Disclosed is anproducing 2-deoxy-scyllo-inosose (DOI), which, from a sucrose non-PTS gene group, has at least a sucrose hydrolase (CscA)-encoding gene and which is provided with a DOI production system or has an enhanced DOI production system. Thepreferably further includes a system to enhance sugar uptake capacity. There is also disclosed a method of producing DOI from a plant-derived raw material containing sucrose by using the

Bacterium producing 2-deoxy-scyllo-inosose (DOI) and method of producing 2-deoxy-scyllo-inosose (DOI) by using same

The present invention provides: a lactic acid-producingcomprising at least one gene of a sucrose non-PTS gene group, including at least a sucrose hydrolase gene, provided that a combination of a repressor protein (cscR), a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) and a combination of a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) are excluded, wherein the lactic acid-producingcomprises a lactic acid production enhancing system provided by genetic recombination; and a lactic acid production method including producing lactic acid from a plant-derived sucrose-containing raw material by using the lactic acid-producing

Method for producing lactic acid from plant-derived raw material, and lactic-acid-producing bacterium

A method for producing D-lactic acid in high yield, and to provide a method for producing D-lactic acid with high selectivity, in which optical purity is high and a by-product organic acid is small. In one aspect, a microorganism, wherein activity of pyruvate formate-lyase (pfl) is inactivated or decreased, and further activity of-derived NADH-dependent D-lactate dehydrogenase (ldhA) is enhanced, is cultured to efficiently produce D-lactic acid. With regard to a method for enhancing ldhA activity, by linking, on a genome, a gene encoding ldhA with a promoter of a gene which controls expression of a protein involved in a glycolytic pathway, a nucleic acid biosynthesis pathway or an amino acid biosynthesis pathway, suitable results are obtained compared to the method for enhancing expression of the gene using an expression vector. A microorganism in which a dld gene is substantially inactivated or decreased is cultured to produce high quality D-lactic acid with reduced concentration of pyruvic acid.

Biocatalyst for production of D-lactic acid

The present invention provides is a method for producing 3-mercaptopropionic acid from 3-mercaptopropionamide or a salt thereof with the use of an amidase. The method enables the production of 3-mercaptopropionic acid on an industrial scale through an enzymatic reaction.

Method for producing 3-mercaptopropionic acid or salt thereof

The present invention provides: a lactic acid-producingincluding an enzymatic activity of at least one NAD-dependent lactate dehydrogenase and an enzymatic activity of at least one NAD-independent lactate oxidoreductase, both of which are enhanced so as to decompose one of D-lactic acid or L-lactic acid and to produce the other one of D-lactic acid or L-lactic acid; and a lactic acid production method using the lactic acid-producing

Bacterium capable of producing lactic acid, and method for producing lactic acid

This invention relates to DNA encoding an enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the enzyme.

The invention provides a method for producing a cytosine nucleoside compound from pentose-1-phosphate and cytosine or a derivative thereof using a nucleoside phosphorylase reactive to cytosine or a bacterium having the enzyme activity. The invention also provides a method for specifically reducing an activity to degrade the substrates or the product, resulting in efficient production of the cytosine nucleoside compound. According to the invention, little by-product is produced in producing cytonucleocide compounds.

Method for producing cytosine nucleoside compounds

A desired isomer is selectively prepared by phosphorolyzing and isomerizing an anomer mixture of a 1-phosphorylated saccharide derivative while crystallizing one of the isomers to displace the equilibrium. Furthermore, using the action of a nucleoside phosphorylase, a nucleoside is prepared from the 1-phosphorylated saccharide derivative obtained and a base with improved stereoselectivity and a higher yield. This process is an anomer-selective process for preparing a 1-phosphorylated saccharide derivative and a nucleoside.

Process for selectively producing 1-phosphorylated sugar derivative anomer and process for producing nucleoside

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Chiba, Japan

Tadashi Araki