Northwestern University

Baxter International Inc.

Baxter Healthcare Sa

Hospira, Inc.

Tadas Stanislovas Sileika

Phillip Byron Messersmith

Ton That Hai

John-Bruce Devault Green

Timothy Michael Fulghum

Devin G Barrett

Ran Zhang

William Kenneth Day

James Duane Jacobson

Wei Zhang

Aaron I Packman

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups

A method of making a facile, surface-independent, polyphenol coating is disclosed. In general, the method includes contacting at least a portion of the substrate to be coated with an aqueous solution containing one or more salts and one or more nitrogen-free phenolic compounds. Substrates of all kinds may be used, and compounds used to make the coating may include epigallocatechin-3-gallate (EGCG), epigallocatechin (EGC) and epicatechin-3-gallate (ECG), tannic acid, gallic acid, pyrogallol, and/or other nitrogen-free phenolic compounds. The coating made using the method, methods of using the coating, and kits comprising the coating precursors are also disclosed.

Phenolic coatings and methods of making and using same

The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

Immobilization of an active agent on a substrate

Enables an infusion pump battery capacity management and battery charge alert system and method including an infusion pump with rechargeable batteries, a controller, a computer and a user interface. The infusion pump accepts a programmed infusion and selects a battery capacity assessment option to determine one or more recharge options of the batteries, and may optionally select a program delay option to execute an infusion delay and later select the battery capacity assessment option. During the battery capacity assessment option, the infusion pump calculates an anticipated power capacity requirement to execute the programmed infusion, calculates a remaining battery power capacity, compares the calculated anticipated power capacity requirement to the calculated remaining battery power capacity, and determines whether the infusion pump is able to fully execute the programmed infusion based only on the remaining battery power capacity or whether a recharge is required.

Infusion pump battery capacity management and battery charge alert system and method

A UV (ultraviolet) light disinfectant apparatus useful with a biofilm flow cell for in-line, non-invasive disinfecting of medium flow to and from the flow cell is provided. The disinfectant apparatus includes a UV chamber having a UV light source therein and one or more UV light-transmissive tubes that extend through the UV chamber and through which the fluid medium flows through the UV chamber for exposure to UV light for purposes of disinfectation.

UV disinfectant device for biofilm flow cell

Growing community of inventors

Northbrook, IL, United States of America

Tadas Stanislovas Sileika